Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2025; 31(17): 106508
Published online May 7, 2025. doi: 10.3748/wjg.v31.i17.106508
Published online May 7, 2025. doi: 10.3748/wjg.v31.i17.106508
Clinicopathological characteristics and prognostic outcomes of pregnancy-associated colorectal cancer: A 24-year experience
Li-Wen Fan, Qi Lin, School of Clinical Medicine, The Hebei University of Engineering, Handan 056000, Hebei Province, China
Chao Shang, Dong-Kui Xu, Department of VIP, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Co-first authors: Li-Wen Fan and Chao Shang.
Co-corresponding authors: Yan-Tao Tian and Dong-Kui Xu.
Author contributions: Fan LW, Shang C, Lin Q, Tian YT, and Xu DK conceived and designed the study and analyzed the data; Fan LW and Shang C interpreted the data and drafted the manuscript, they contributed equally as co-first authors; Lin Q contributed to statistical analysis; Tian YT and Xu DK provided critical feedback and approved the final manuscript, they contributed equally to this manuscript and as co-corresponding authors.
Supported by the National Natural Science Foundation of China, No. 82372989.
Institutional review board statement: The studies involving human participants were supported by the ethics and research committee of the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences (approval number: 24/363-4643).
Informed consent statement: All of the patients’ personal identifiable information was removed before use, and individual consent for this retrospective analysis was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Kui Xu, MD, Chief Physician, Professor, Department of VIP, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. 13691583382@163.com
Received: March 3, 2025
Revised: March 27, 2025
Accepted: April 22, 2025
Published online: May 7, 2025
Processing time: 60 Days and 7.9 Hours
Revised: March 27, 2025
Accepted: April 22, 2025
Published online: May 7, 2025
Processing time: 60 Days and 7.9 Hours
Core Tip
Core Tip: Pregnancy-associated colorectal cancer (pCRC) is a rare disease with a poor prognosis. Research on the prognosis of pCRC, particularly regarding factors influencing maternal and fetal outcomes, remains limited in Asia. This study encompassed all pCRC patients from Chinese cancer centers over a 24-year period and employed rigorous retrospective research methods. The findings highlight that while tumor location and advanced maternal age did not significantly impact survival, tailored strategies balancing maternal and fetal health are crucial, especially in cases of poorly differentiated tumors and advanced-stage disease.