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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2025; 31(16): 105188
Published online Apr 28, 2025. doi: 10.3748/wjg.v31.i16.105188
Published online Apr 28, 2025. doi: 10.3748/wjg.v31.i16.105188
Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease
Jia-Wei Yu, Qi Zhao, Pei-Xi Li, Ya-Xuan Zhang, Bi-Xuan Gao, Lin-Biao Xiang, Xiao-Yu Liu, Lei Wang, Yi-Jie Sun, Ze-Zhou Yang, Yu-Jia Shi, Yun-Fei Chen, Meng-Bo Yu, Yi Lyu, Feng-Gang Ren, Qiang Lu, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Hong-Ke Zhang, Department of Pediatric Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Lei Zhang, Qin-Hong Xu, Dan Li, Qiang Lu, Department of Abdominal Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Lu Ren, Department of International Medical Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yi Lyu, Feng-Gang Ren, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Co-corresponding authors: Feng-Gang Ren and Qiang Lu.
Author contributions: Lu Q and Ren FG generated conceptualization; Yu JW, Zhao Q, Liu XY, Wang L, and Li PX contributed to methodology; Yu JW contributed to software; Zhao Q, Zhang YX, Sun YJ, Yang ZZ, Gao BX, and Xiang LB contributed to validation; Yu JW and Zhang L contributed to formal analysis; Yu JW and Lu Q contributed to investigation; Lu Q and Ren FG contributed to resources; Yu JW, Xu QH, Ren L, and Li D contributed to data curation; Yu JW, Shi YJ, Chen YF, Yu MB, and Ren FG wrote original draft; Lyu Y and Lu Q contributed to writing, review, and editing; Lu Q contributed to visualization; Lyu Y, Ren FG, and Lu Q supervised the study; Yu JW, Zhao Q, Li PX, Zhang YX, and Gao BX contributed to project administration; Lyu Y and Ren FG contributed to funding acquisition; Ren FG and Lu Q contributed equally as co-corresponding authors; Yu JW, Zhao Q, Li PX, Zhang YX, Gao BX, Xiang LB, Liu XY, Wang L, Sun YJ, Yang ZZ, Shi YJ, Chen YF, Yu MB, Zhang HK, Zhang L, Xu QH, Ren L, Li D, Lyu Y, Ren FG, and Lu Q have read and agreed to the published version of the manuscript.
Supported by the National Key Research and Development Program, No. 2023YFF0713700 and No. 2023YFF0713705; Common Technology R&D Platform of Shaanxi Province, No. 2023GXJS-01-1-2; and the Cyrus Tang Foundation Chung Ying Young Scholars Program.
Institutional animal care and use committee statement: This study was conducted in accordance with the guidelines and approved by the Animal Experiment Ethics Committee of Xi’an Jiaotong University (No. XJTUAE2025-10).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data presented in this study are available upon request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiang Lu, MD, PhD, Department of Abdominal Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. luqiang2020@xjtufh.edu.cn
Received: January 15, 2025
Revised: March 17, 2025
Accepted: March 31, 2025
Published online: April 28, 2025
Processing time: 102 Days and 16.4 Hours
Revised: March 17, 2025
Accepted: March 31, 2025
Published online: April 28, 2025
Processing time: 102 Days and 16.4 Hours
Core Tip
Core Tip: This study assessed the feasibility and effectiveness of simple duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) in non-alcoholic fatty liver disease rat model. After DMA using IRE, the duodenal wall structure changed and appeared to return to normal when compared to the sham-control group, while liver lipid deposition reduced and serum lipid parameters considerably improved. Also, changes in the intestinal endocrine system were observed. Therefore, by altering enteroendocrine and duodenal permeability, simple DMA using IRE ameliorated liver lipid deposition in non-alcoholic fatty liver disease rats.