Liang ZF, Xu YM, Song JJ, Gao ZH, Qian H, Xu XZ. Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. World J Gastroenterol 2025; 31(16): 104920 [DOI: 10.3748/wjg.v31.i16.104920]
Corresponding Author of This Article
Zhao-Feng Liang, MD, Doctor, Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Tianning District, Changzhou 213017, Jiangsu Province, China. liangzhaofeng@ujs.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 28, 2025; 31(16): 104920 Published online Apr 28, 2025. doi: 10.3748/wjg.v31.i16.104920
Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis
Zhao-Feng Liang, Xue-Zhong Xu, Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213017, Jiangsu Province, China
Zhao-Feng Liang, Yu-Meng Xu, Jia-Jia Song, Zi-Han Gao, Hui Qian, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China
Co-first authors: Zhao-Feng Liang and Yu-Meng Xu.
Co-corresponding authors: Zhao-Feng Liang and Xue-Zhong Xu.
Author contributions: Xu YM and Liang ZF wrote the manuscript; Xu YM, Song JJ, and Gao ZH conducted the data analyses; Xu YM prepared the figures; Xu XZ, Qian H, and Liang ZF contributed to the editing and revision of the manuscript; All authors reviewed the manuscript.
Supported by the National Natural Science Foundation of China, No. 81602883; Technology Development Project of Jiangsu University, No. 20220516; and Postgraduate Research and Practice Innovation Program of Jiangsu Province, No. KYCX233765.
Institutional review board statement: This study was exclusively focused on cellular research and did not involve animal models or human samples. This study was reviewed and approved by the Wujin Hospital Affiliated with Jiangsu University Institution Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: All data generated or analyzed in this study are included in this published article. Dataset available from the first author at liangzhaofeng@ujs.edu.cn. Participants gave informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Feng Liang, MD, Doctor, Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Tianning District, Changzhou 213017, Jiangsu Province, China. liangzhaofeng@ujs.edu.cn
Received: January 10, 2025 Revised: February 25, 2025 Accepted: April 7, 2025 Published online: April 28, 2025 Processing time: 111 Days and 1.6 Hours
Core Tip
Core Tip: Hesperetin, a citrus flavonoid, shows potential in inhibiting gastric cancer initiation and progression, but via unclear mechanisms. This study explored its role in countering N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric carcinogenesis mediated by exosomal circular RNA. Bioinformatics and biological experiments revealed that exosomes from TGES-1 cells enhanced GES-1 cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness, but hesperetin pretreatment significantly reduced these effects. Hesperetin targeted exosomal circ0008274, which interacts with microRNA-526b-5p, to inhibit cancer-inducing properties. Overexpression or knockdown of circ0008274 confirmed its role in promoting GES-1 cell proliferation, EMT, and stemness via miR-526b-5p. Hesperetin intervenes in gastric carcinogenesis by modulating the exosomal circ0008274/miR-526b-5p axis.
