Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2025; 31(15): 104875
Published online Apr 21, 2025. doi: 10.3748/wjg.v31.i15.104875
Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice
Xin-Yu Wang, Fang Liu, Qi-Tong Wang, Shu-Zhu Li, Yu-Zhao Ye, Tao Chen, Ben-Chi Cai
Xin-Yu Wang, Fang Liu, Qi-Tong Wang, Shu-Zhu Li, Yu-Zhao Ye, Tao Chen, Ben-Chi Cai, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 570100, Hainan Province, China
Co-first authors: Xin-Yu Wang and Fang Liu.
Co-corresponding authors: Tao Chen and Ben-Chi Cai.
Author contributions: Chen T and Cai BC conceptualized and designed the research; Wan XY and Liu F screened patients and acquired clinical data; Wan XY and Liu F collected samples and performed laboratory analysis; Li SZ, Ye YZ, and Wang QT performed data analysis; Wan XY and Cai BC wrote the paper; All the authors have read and approved the final manuscript. Liu F was also responsible for patient screening, enrollment, collection of clinical data. Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Both Chen T and Cai BC have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Cai BC applied for and obtained the funds for this research project. Cai BC conceptualized, designed, and supervised the whole process of the project. He searched the literature, revised and submitted the early version of the manuscript. Chen T was instrumental and responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search. This collaboration between Chen T and Cai BC is crucial for the publication of this manuscript and other manuscripts still in preparation.
Supported by the Hainan Provincial Natural Science Foundation of China, No. 823MS133 and No. 821QN0979.
Institutional animal care and use committee statement: The animal study protocol was reviewed and approved by the Animal Ethics Committee of Hainan Medical University, No. 2024[148]. All animal procedures were conducted in accordance with the guidelines for the care and use of laboratory animals.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request at caibenchi@hainmc.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ben-Chi Cai, Professor, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570100, Hainan Province, China. caibenchi@hainmc.edu.cn
Received: January 5, 2025
Revised: February 24, 2025
Accepted: March 24, 2025
Published online: April 21, 2025
Processing time: 103 Days and 21.2 Hours
Core Tip

Core Tip: The specific objectives of this study are to identify key molecular targets of rhapontin, evaluate its impact on gastrointestinal symptoms in Parkinson's disease, and investigate its anti-inflammatory effects mediated by nuclear factor erythroid 2-related factor 2 activation.