Delaying liver aging: Analysis of structural and functional alterations

doi:10.3748/wjg.v31.i15.103773

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Apr 21, 2025 (publication date) through Apr 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2025; 31(15): 103773
Published online Apr 21, 2025. doi: 10.3748/wjg.v31.i15.103773

Delaying liver aging: Analysis of structural and functional alterations

Yu-Qin Yao, Qiong-Yue Cao, Zheng Li

Yu-Qin Yao, Qiong-Yue Cao, Zheng Li, College of Health Sciences, School of Life Sciences, Jiangsu Normal University, Xuzhou 221000, Jiangsu Province, China

Author contributions: Yao YQ and Cao QY contributed to analysis of data, drafting the article, and final approval; Li Z contributed to design of the study, revising the article, and final approval.

Supported by the National Natural Science Foundation of China, No. 82104525; and Open Foundation of Key Laboratory of Tropical Plant Resource Chemistry of Hainan Province, No. rdzw2024s01.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Zheng Li, PhD, College of Health Sciences, School of Life Sciences, Jiangsu Normal University, No. 101 Shanghai Road, Xuzhou 221000, Jiangsu Province, China. lizhengcpu@163.com

Received: December 3, 2024
Revised: February 23, 2025
Accepted: April 7, 2025
Published online: April 21, 2025
Processing time: 139 Days and 21.9 Hours

Core Tip

Core Tip: The natural aging process can impair liver functions, including regeneration and metabolism, disrupting hepatic balance and increasing the risk of liver diseases. Cellular and morphological changes are attributable to altered molecular mechanisms. Comprehending the processes of hepatocyte senescence is essential for delaying liver aging through appropriate lifestyle modifications, pinpointing triggers, devising therapeutic strategies, and assessing the effectiveness of interventions against liver diseases. Consequently, it is imperative to conduct further research on the molecular pathways involved.