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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2025; 31(14): 104584
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.104584
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.104584
Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study
Tian-Wei Wang, Lu-Lu Zhou, Hao-Ran Wang, Ting-Ting Yu, Ji-Chao Zhai, Wei Jiang, Jiang-Quan Yu, Rui-Qiang Zheng, Department of Intensive Care Unit, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Jing Yuan, Department of Functional Examination, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Wen-Xin Zhou, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Cheng-Bin Tang, Jun Shao, Department of Center for Cardiac Macrovascular Disease, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Hai-Long Yu, Department of Neuro Intensive Care Unit, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Hai-Long Yu, Department of Neurology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Co-first authors: Tian-Wei Wang and Lu-Lu Zhou.
Co-corresponding authors: Hai-Long Yu and Jun Shao.
Author contributions: Yu HL and Shao J contributed equally to this study as co-corresponding authors; Yu HL and Shao J conceived and planned this study; Wang TW and Zhou LL contributed equally to this study as co-first authors; Wang TW and Zhou LL performed the vast majority of the data acquisition and analysis for this experiment; Yuan J, Zhou WX, Wang HR, Yu TT, Zhai JC, and Jiang W performed the remaining data collection and analysis; Wang TW wrote the first draft of the manuscript; Tang CB, Yu JQ, and Zheng RQ were responsible for the execution and supervision of the entire project.
Supported by the National Science Foundation of Jiangsu Province, No. BK20221280; the National Natural Science Foundation of China, No. 82371336; the Chinese Postdoctoral Science Foundation, No. 2022M711426; the Special Fund for Social Key Research and Development Plan of Yangzhou City, No. YZ2022097; Yangzhou Municipal Science and Technology Bureau, No. YZ2024091 and No. YZ2022098.
Institutional review board statement: The medical research ethics committee of the Northern Jiangsu People’s Hospital provided approval for this study (ethics number: 2023ky297).
Informed consent statement: All patients were informed about the process and purpose of this study, voluntarily participated, and signed an informed consent form.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Shao, Associate Chief Physician, Department of Center for Cardiac Macrovascular Disease, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, No. 98 Nantong Road West, Guangling District, Yangzhou 225001, Jiangsu Province, China.
Received: December 25, 2024
Revised: February 17, 2025
Accepted: March 25, 2025
Published online: April 14, 2025
Processing time: 107 Days and 10.4 Hours
Revised: February 17, 2025
Accepted: March 25, 2025
Published online: April 14, 2025
Processing time: 107 Days and 10.4 Hours
Core Tip
Core Tip: Sepsis-associated liver injury (SALI) refers to secondary liver function impairment caused by sepsis, the SALI patients often have worse clinical outcomes. Recent evidence has suggested that iron metabolism plays a significant role in the adverse processes of sepsis and sepsis-induced organ damage. Our research indicates that iron metabolism disorders are closely related to the occurrence and development of SALI and that serum iron and total iron-binding capacity can serve as potential predictive indicators for SALI. These findings provide valuable information for further exploration of the mechanisms underlying the occurrence of SALI and the development of new treatment strategies.