Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2025; 31(14): 104117
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.104117
Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease
Feng Zhu, Bing-Ru Lin, Shi-Hua Lin, Chao-Hui Yu, Yun-Mei Yang
Feng Zhu, Shi-Hua Lin, Yun-Mei Yang, Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Bing-Ru Lin, Chao-Hui Yu, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Yun-Mei Yang, Key Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, Hangzhou 310003, Zhejiang Province, China
Co-corresponding authors: Chao-Hui Yu and Yun-Mei Yang.
Author contributions: Yu CH and Yang YM designed and supervised the study; Zhu F, Lin BR, and Lin SH performed the experiments and acquired and analyzed the data; Zhu F and Lin BR interpreted the data; Zhu F wrote the manuscript; All authors approved the final version of the article; Yu CH and Yang YM contributed equally to this work in the design and supervision of the study, and review and revision of the paper, meriting the co-corresponding authorship designation.
Supported by the National Natural Science Foundation of China, No. 820300089.
Institutional review board statement: The study did not involve human participants, human data, or human tissue.
Institutional animal care and use committee statement: All animal procedures were approved by the Ethics Committee of The First Affiliated Hospital, Zhejiang University School of Medicine (No. 2024-1652).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Hui Yu, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn
Received: December 11, 2024
Revised: February 21, 2025
Accepted: March 21, 2025
Published online: April 14, 2025
Processing time: 121 Days and 20.3 Hours
Core Tip

Core Tip: We showed that aging exacerbated the pathogenesis of metabolic dysfunction-associated steatotic liver disease. Hepatic-specific knockdown of vitamin D receptor alleviated the progression of aging-related metabolic dysfunction-associated steatotic liver disease. Vitamin D receptor is a crucial factor implicated in steatosis.