Interplay of genetic and clinical factors in cancer-associated thrombosis: Deciphering the prothrombotic landscape of colorectal cancer

doi:10.3748/wjg.v31.i14.103901

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Apr 14, 2025 (publication date) through Apr 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2025; 31(14): 103901
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.103901

Interplay of genetic and clinical factors in cancer-associated thrombosis: Deciphering the prothrombotic landscape of colorectal cancer

Duo-Gang Xu, Jing Tan

Duo-Gang Xu, Jing Tan, Department of General Surgery, Yan'an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China

Duo-Gang Xu, Jing Tan, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming 650051, Yunnan Province, China

Author contributions: Xu DG contributed significantly to the conceptualization, writing and design of the article; Tan J contributed to the drafting of the article and provided critical revisions of significant intellectual content; all authors prepared the draft and approved the submitted version.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jing Tan, PhD, Professor, Department of General Surgery, Yan'an Hospital Affiliated to Kunming Medical University, No. 245 Renmin East Road, Panlong District, Kunming 650051, Yunnan Province, China. jingtan0915@163.com

Received: December 4, 2024
Revised: March 3, 2025
Accepted: March 25, 2025
Published online: April 14, 2025
Processing time: 128 Days and 12.6 Hours

Core Tip

Core Tip: This comprehensive review examines the complex interplay between genetic and clinical factors in colorectal cancer (CRC)-associated thrombosis. It highlights how tumor-specific mechanisms, such as tissue factor and cancer procoagulant, actively contribute to the coagulation cascade, alongside clinical risk factors like age, gender, and obesity. By integrating both tumor biology and patient-specific characteristics, this study provides crucial insights into the prothrombotic tendencies of CRC, offering valuable perspectives for personalized therapies and improving patient management in CRC-associated venous thromboembolism.