Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2025; 31(14): 103892
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.103892
Efficacy of a novel artificial liver versatile plasma purification system in patients with acute-on-chronic liver failure
Zhong-Shang Dai, Min Zhang, Yuan-Ye Deng, Ning Zhou, Yi Tian
Zhong-Shang Dai, Min Zhang, Yuan-Ye Deng, Ning Zhou, Yi Tian, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Co-first authors: Zhong-Shang Dai and Min Zhang.
Author contributions: Dai ZS and Zhang M contributed equally to this article; Dai ZS and Zhang M wrote the main manuscript text and prepared figures and tabs; Tian Y designed the study; Deng YY is responsible for data collecting; Zhou N analyzed all data; All authors reviewed the manuscript.
Supported by Natural Science Foundation of Hunan Province, China, No. 2022JJ30842 and No. 2024JJ6560; Clinical Medical Research Center for Viral Hepatitis of Hunan Province, No. 2023SK4009; and Beijing iGandan Foundation, No. RGGJJ-2021-017 and No. iGandanF-1082022-RGG023.
Institutional review board statement: The research was approved by the Ethics Committee of the Second Xiangya Hospital, No. 2022-53.
Clinical trial registration statement: This trial was registered at http://clinicaltrials.gov as (NCT06377774).
Informed consent statement: All study participants or their legal guardian provided informed written consent regarding personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: All data of this study are available from the corresponding author Yi Tian for reasonable request at tianyi@csu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Tian, MD, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. tianyi@csu.edu.cn
Received: December 5, 2024
Revised: February 5, 2025
Accepted: March 26, 2025
Published online: April 14, 2025
Processing time: 128 Days and 17.8 Hours
Core Tip

Core Tip: In this study, we introduced a novel artificial liver support model, termed the Versatile Plasma Purification System (VPPS), aimed at treating patients with acute-on-chronic liver failure (ACLF). We demonstrated that the VPPS significantly enhances liver function, coagulation parameters, and blood ammonia levels in ACLF patients, as evidenced by a comparative analysis of laboratory data obtained prior to and following treatment with both VPPS and non-VPPS modes. Furthermore, our analysis revealed that patients receiving VPPS treatment exhibited reduced rates of readmission and mortality throughout the long-term follow-up period.