Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2025; 31(13): 102563
Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.102563
Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study
Lin Ye, Kai Yan, Ze Tian, Zhi-Hua Xiao, Ru-Yi Xie, Zheng-Yuan Xie, Li Tao
Lin Ye, Zhi-Hua Xiao, Ru-Yi Xie, Zheng-Yuan Xie, Li Tao, Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China
Kai Yan, Ze Tian, Department of Pediatrics, The First Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China
Co-first authors: Lin Ye and Kai Yan.
Author contributions: Ye L and Yan K provided equivalent and substantial contributions to this manuscript, whereby they jointly established the theoretical framework for the study and were responsible for drafting the initial manuscript; Tian Z, Xiao ZH, Xie RY and Xie ZY conducted the data collection, statistical analysis, and interpretation; as the corresponding author, Tao L played a significant role in guiding the manuscript's progress and ensuring its internal consistency while also proposing enhancements for the manuscript; the final manuscript was meticulously reviewed and approved by all of the contributing authors, thus ensuring academic rigor and integrity.
Supported by Science and Technology Research Program of Jiangxi Provincial Department of Education, No. GJJ210225; 2022 Provincial Health and Wellness Committee Science and Technology Program Projects, No. 20221096; and Jiangxi Provincial Natural Science Foundation's Young Scientists Fund, No. 20242BAB20358.
Institutional review board statement: This study was reviewed and approved by the Clinical Medical Research Ethics Committee of the Second Affiliated Hospital of Nanchang University.
Informed consent statement: A waiver of informed consent being obtained for the clinical research.
Conflict-of-interest statement: No potential conflicts of interest were reported by the author(s).
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data used in this study are available upon reasonable request to the corresponding author (Li Tao) following approval by the Clinical Medical Research Ethics Committee of the Second Affiliated Hospital of Nanchang University.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Tao, Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, No. 01 Minde Road, Nanchang 330008, Jiangxi Province, China. ndefy17088@ncu.edu.cn
Received: October 22, 2024
Revised: February 19, 2025
Accepted: March 12, 2025
Published online: April 7, 2025
Processing time: 162 Days and 17.3 Hours
Core Tip

Core Tip: This large cross-sectional study involving 28624 adults revealed that Helicobacter pylori (H. pylori) infection is correlated with metabolic disturbances, particularly in obese and older individuals. H. pylori-positive individuals exhibited elevated blood glucose, low-density lipoprotein cholesterol, and blood pressure levels, with worse metabolic profiles being observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). High blood glucose, body mass index, and diastolic pressure levels were identified as significant risk factors for H. pylori infection, whereas high-density lipoprotein was observed to be a protective factor. These findings suggest that H. pylori infection may contribute to metabolic disorders and MASLD progression, thereby offering insights for future research and prevention strategies.