Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2025; 31(12): 99846
Published online Mar 28, 2025. doi: 10.3748/wjg.v31.i12.99846
Peroral endoscopic myotomy for achalasia and patients with normal lower-esophageal-sphincter integrated relaxation pressure: A propensity-score-matched retrospective study
Xiao Li, Xiao-Bin Zhang, Jia-Kang Shao, Bo Zhang, Long-Song Li, Rui-Qing Zhu, Jia-Le Zou, Jia-Feng Wang, Xin Zhao, Qing-Zhen Wu, Ning-Li Chai, En-Qiang Linghu
Xiao Li, Department of General Medicine, The Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China
Xiao Li, Xiao-Bin Zhang, Bo Zhang, Long-Song Li, Rui-Qing Zhu, Jia-Le Zou, Jia-Feng Wang, Xin Zhao, Qing-Zhen Wu, Ning-Li Chai, En-Qiang Linghu, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Jia-Kang Shao, Medical School of Chinese PLA, Beijing 100853, China
Co-first authors: Xiao Li and Xiao-Bin Zhang.
Co-corresponding authors: Ning-Li Chai and En-Qiang Linghu.
Author contributions: Li X, Zhang XB, Chai NL and Linghu EQ conceived and designed the study; Zhang B, Li LS, Zhu RQ, Zou JL, Wang JF, Zhao X and Wu QZ contributed to the acquisition of data; Li X, Shao JK and Zhang XB did data analysis and interpretation; All the authors have read and approved the final manuscript. Li X and Zhang XB were co-first authors. Chai NL and Linghu EQ critically revised the article. Chai NL and Linghu EQ contributed equally to this paper and were co-corresponding authors.
Institutional review board statement: This study was approved by the ethics committee of Chinese PLA General Hospital (Approval No. S2021-206-01).
Informed consent statement: Informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request at linghuenqiang@vip.sina.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-Qiang Linghu, MD, PhD, Chief Doctor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Received: August 1, 2024
Revised: February 1, 2025
Accepted: March 3, 2025
Published online: March 28, 2025
Processing time: 237 Days and 2.9 Hours
Core Tip

Core Tip: Peroral endoscopic myotomy (POEM) has been confirmed to be effective at relieving the clinical symptoms of achalasia associated with increased lower esophageal sphincter (LES) pressure. However, there are few studies on safety and efficacy of POEM for patients with normal LES integrated relaxation pressure (LES-IRP). Therefore, we conducted a retrospective and found that POEM is safe and effective for achalasia and patients with normal LES-IRP. And POEM was not associated with a greater incidence of reflux symptoms in patients with normal LES-IRP.