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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2025; 31(11): 104377
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.104377
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.104377
Development and validation of a predictive model for the pathological upgrading of gastric low-grade intraepithelial neoplasia
Kun-Ming Lyu, Jun Wan, Department of Gastroenterology, The Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Kun-Ming Lyu, Yao-Qian Yuan, Medical College, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Qian-Qian Chen, Yao-Qian Yuan, Jia-Feng Wang, En-Qiang Ling-Hu, Department of Gastroenterology, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Yi-Fan Xu, Department of Gastroenterology, General Hospital of Central Theater Command, Wuhan 430000, Hubei Province, China
Co-first authors: Kun-Ming Lyu and Qian-Qian Chen.
Co-corresponding authors: Jun Wan and En-Qiang Ling-Hu.
Author contributions: Ling-Hu EQ, Wan J, and Chen QQ designed the research; Lyu KM and Yuan YQ played key roles in data collection; Lyu KM and Chen QQ contributed equally as co-first authors; Xu YF and Wang JF provided statistical expertise and editorial assistance; Lyu KM wrote the manuscript; Ling-Hu EQ and Wan J oversaw the project and contributed equally as co-corresponding authors; and all authors participated in a thorough review and refinement of the manuscript and approved its final version for publication.
Supported by the National Key Research and Development Program of China, No. 2022YFC2503600.
Institutional review board statement: The study protocol was reviewed and approved by the Ethics Committee of the Chinese People’s Liberation Army General Hospital (Ethics audits No. S2023-188-01).
Informed consent statement: Patients were not required to provide informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to MR surgery by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement:
All data obtained or analyzed during this work are included within the article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-Qiang Ling-Hu, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Received: December 20, 2024
Revised: January 17, 2025
Accepted: February 11, 2025
Published online: March 21, 2025
Processing time: 83 Days and 2.7 Hours
Revised: January 17, 2025
Accepted: February 11, 2025
Published online: March 21, 2025
Processing time: 83 Days and 2.7 Hours
Core Tip
Core Tip: This study developed and validated a predictive model for the pathological upgrading of gastric low-grade intraepithelial neoplasia using clinical and endoscopic characteristics. The least absolute shrinkage and selection operator (LASSO) regression analysis identified nine key predictors from 30 variables related to pathological upgrading. The LASSO model demonstrated an area under the curve of 0.904, and internal validation with 30% of the data yielded an area under the curve of 0.905, confirming its clinical utility.