Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway

doi:10.3748/wjg.v31.i11.103449

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Mar 21, 2025; 31(11): 103449
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103449

Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway

Yan-Min Chen, Wen-Qian Yang, Ying-Ying Fan, Zhi Chen, Yu-Zhen Liu, Bao-Sheng Zhao

Yan-Min Chen, Wen-Qian Yang, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China

Yan-Min Chen, Department of Oncology, The First Affiliated Hospital of Henan Polytechnic University, Jiaozuo 454000, Henan Province, China

Wen-Qian Yang, Yu-Zhen Liu, Bao-Sheng Zhao, Henan Medical Science Key Laboratory of Esophageal Cancer Metastasis Translational Medicine, Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China

Wen-Qian Yang, Yu-Zhen Liu, Life Science Research Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China

Ying-Ying Fan, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China

Zhi Chen, Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China

Co-first authors: Yan-Min Chen and Wen-Qian Yang.

Co-corresponding authors: Yu-Zhen Liu and Bao-Sheng Zhao.

Author contributions: All authors contributed to the study’s conception and design; Chen YM, Liu YZ, and Zhao BS made contributions to the conception and design of this study; Chen YM, Yang WQ and Chen Z conducted experiments; Fan YY, Yang WQ and Zhao BS were responsible for clinical sample collection; Chen Y and Yang WQ participated in data analysis; Chen YM, Liu YZ, Yang WQ and Zhao BS wrote the manuscript.

Supported by the Henan Province Science and Technology Development Plan, No. 242102311124; Key Medical Scientific and Technological Project of Henan Province, No. SBGJ202102188; Henan Provincial Medical Science and Technology Project, No. LHGJ20221012; and Fundamental Research Funds for the Universities of Henan Province, No. NSFRF240308.

Institutional review board statement: This study was reviewed and approved by the First Affiliated Hospital of Xinxiang Medical University Institutional Review Board (Approval No. EC-024-559).

Institutional animal care and use committee statement: This study does not involve any animal experimentation.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Bao-Sheng Zhao, MD, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China. drbszhao@xxmu.edu.cn

Received: November 25, 2024
Revised: January 9, 2025
Accepted: February 14, 2025
Published online: March 21, 2025
Processing time: 111 Days and 1.3 Hours

Core Tip

Core Tip: This study revealed that trichostatin A (TSA), a histone deacetylase inhibitor (HDACi), promoted the migration of esophageal squamous cell carcinoma (ESCC) cells by facilitating epithelial-mesenchymal transition (EMT) through the bromodomain-containing protein (BRD4)/cellular myelocytomatosis oncogene (c-Myc)/endoplasmic reticulum (ER) stress pathway. Mechanistically, TSA-induced histone acetylation enhances BRD4 recruitment and c-Myc expression, which triggers ER stress and subsequently drives EMT. Clinical analyses demonstrated a negative correlation between histone acetylation levels and ESCC prognosis, providing novel insights into the molecular mechanisms of ESCC migration and the implications of HDACi therapy.