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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2025; 31(11): 103412
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103412
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103412
Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer
Ze-Song Meng, Ji-Tao Hu, Bao-Kun Li, Second Departments Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Hao Wu, Clinical Laboratory of East Hospital, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Meng ZS and Li BK designed the experiments and conducted clinical data collection; Hu JT and Wu H performed postoperative follow-up and recorded the data; Meng ZS and Li BK conducted the collation and statistical analysis, and wrote the original manuscript and revised the paper; and all authors read and approved the final manuscript.
Supported by the Medical Science Research Project Plan of the Hebei Provincial Health Commission, No. 20210027.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Fourth Hospital of Hebei Medical University.
Institutional animal care and use committee statement: Institutional animal care and use committee statement: All animal experiments were approved by the Ethics Committee of the Fourth Hospital of Hebei Medical University (No. 20250158).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Kun Li, MD, Second Departments Surgery, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. libaokun@hebmu.edu.cn
Received: November 26, 2024
Revised: January 10, 2025
Accepted: February 8, 2025
Published online: March 21, 2025
Processing time: 107 Days and 4.5 Hours
Revised: January 10, 2025
Accepted: February 8, 2025
Published online: March 21, 2025
Processing time: 107 Days and 4.5 Hours
Core Tip
Core Tip: This study suggested that serpin family B member 5 (SERPINB5) was significantly upregulated in rectal cancer tissues and cell lines. SERPINB5 overexpression increased SW480 cell proliferation and invasion while reducing apoptosis. By contrast, SERPINB5 knockdown had the opposite effects. Moreover, SERPINB5 knockdown retarded the growth of rectal cancer tumors in vivo. Mechanistically, SERPINB5 interacted with heat shock protein 90 alpha family class A member 1 and promoted heat shock protein 90 alpha family class A member 1 expression in SW480 cells.