Basic Study
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World J Gastroenterol. Mar 14, 2025; 31(10): 99583
Published online Mar 14, 2025. doi: 10.3748/wjg.v31.i10.99583
Circular RNA contributes to gastric cancer by targeting Wnt family member 2B as a competing endogenous RNA
Wei Bai, Zong-Liang Guo, Jiang-Hong Guo, Feng Li, Peng Bu, Juan Liu
Wei Bai, Zong-Liang Guo, Peng Bu, Department of Pathology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, Shanxi Province, China
Jiang-Hong Guo, Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, Shanxi Province, China
Feng Li, Department of Cell Biology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, Shanxi Province, China
Juan Liu, Department of Special Needs Medicine, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, Shanxi Province, China
Co-first authors: Wei Bai and Zong-Liang Guo.
Author contributions: Bai W and Guo ZL are co-first authors and contributed equally to this work, including design of the study, acquiring and analyzing data from experiments, and writing of the manuscript; Bai W, Guo ZL, Li F and Bu P designed the experiments and conducted clinical data collection; Bai W, Guo ZL, Guo JH and Liu J performed postoperative follow-up and recorded the data, conducted the collation and statistical analysis, and wrote the original manuscript and revised the paper; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Shanxi Province Cancer Hospital.
Institutional animal care and use committee statement: This study did not involve any animal experiments.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan Liu, Department of Special Needs Medicine, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Employee New Village, Xinghualing District, Taiyuan 030013, Shanxi Province, China. liujuan8291@163.com
Received: October 23, 2024
Revised: December 26, 2024
Accepted: January 23, 2025
Published online: March 14, 2025
Processing time: 125 Days and 16.8 Hours
Core Tip

Core Tip: This article explores the functions of circular RNAs (hsa_circRNA_102415) in the malignant behavior and potential downstream signaling of gastric cancer (GC) cells. The experimental content of this article utilizes sponge like microRNA-4529-5p to successfully activate the potential of WNT2B, clarify the role of hsa_circRNA_102415 in GC cells, and provide reference for other researchers to develop targeted treatment plans.