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World J Gastroenterol. Mar 14, 2025; 31(10): 102289
Published online Mar 14, 2025. doi: 10.3748/wjg.v31.i10.102289
Overcoming antibiotic-resistant Helicobacter pylori infection: Current challenges and emerging approaches
Gabriel Reis Rocha, Fabian Fellipe Bueno Lemos, Luis Guilherme de Oliveira Silva, Marcel Silva Luz, Gabriel Lima Correa Santos, Samuel Luca Rocha Pinheiro, Mariana Santos Calmon, Fabrício Freire de Melo
Gabriel Reis Rocha, Fabian Fellipe Bueno Lemos, Luis Guilherme de Oliveira Silva, Marcel Silva Luz, Gabriel Lima Correa Santos, Samuel Luca Rocha Pinheiro, Mariana Santos Calmon, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Author contributions: Rocha GR, Lemos FFB, and de Melo FF contributed to the conceptualization of the manuscript; Rocha GR, Lemos FFB, Silva LGO, Luz MS, Correa Santos GL, Correa Santos GL, Rocha Pinheiro SL, and Calmon MS contributed to the investigation and wrote the original draft; Rocha GR and Silva LGO developed the tables and figures; Rocha GR and de Melo FF were responsible for manuscript editing and review; de Melo FF supervised the writing of the original draft.
Supported by the Industrial Technological Initiation Scholarship of National Council for Scientific and Technological Development, CNPq, Brazil, No. 0932204294929829 and No. 7414780530977345; the Scientific Initiation Scholarship Programme (PIBIC) of National Council for Scientific and Technological Development, CNPq, Brazil, No. 5763023359532159, No. 6472982965854452, and No. 7340128440641417; the Scientific Initiation Scholarship Programme (PIBIC) of Bahia State Research Support Foundation, FAPESB, Brazil, No. 19.573.301.5418; the PERMANECER Programme of Pro-Rectory of Student Assistance at Federal University of Bahia, No. R8EZ-4V4W-6LQX-5LC8; and the CNPq Research Productivity Fellow, No. 4357511882624145.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Received: October 13, 2024
Revised: November 28, 2024
Accepted: January 17, 2025
Published online: March 14, 2025
Processing time: 135 Days and 5.6 Hours
Core Tip

Core Tip: The rise of antibiotic resistance in Helicobacter pylori (H. pylori) has become a global concern and led to the reduction of efficacy of conventional therapies. Resistant H. pylori strains, often inadequately mapped by regional surveillance, frequently demand multiple eradication attempts, imposing considerable financial burdens and adverse effects and contributing to secondary resistance development. This study aimed to provide a comprehensive review of the current landscape of mechanisms and prevalence of H. pylori resistance and to summarize promising therapeutic alternatives under evaluation. These strategies might improve treatment efficacy, enhancing patient outcomes in this challenging scenario.