Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2025; 31(10): 100444
Published online Mar 14, 2025. doi: 10.3748/wjg.v31.i10.100444
Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms
Xiao-Long Zhang, Yang-Yang Jiang, Ying-Ying Chang, Yu-Li Sun, Ying Zhou, Yao-Hui Wang, Xiao-Tan Dou, Hui-Min Guo, Ting-Sheng Ling
Xiao-Long Zhang, Yu-Li Sun, Ying Zhou, Ting-Sheng Ling, Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Yang-Yang Jiang, Ying-Ying Chang, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Yao-Hui Wang, Department of Pathology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Xiao-Tan Dou, Hui-Min Guo, Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China
Co-first authors: Xiao-Long Zhang and Yang-Yang Jiang.
Author contributions: Zhang XL, Jiang YY, and Ling TS designed the research study; Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, and Guo HM performed the research. Both of Zhang XL and Jiang YY have made equally significant contributions to the work and share equal responsibility and accountability for it as co-first authors of this manuscript.
Supported by National Natural Science Foundation of China, No. 82004298; and Jiangsu Graduate Research and Practice Innovation Program, China, No. KYCX23_2090.
Institutional review board statement: The study was reviewed and approved by the Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine Committee (approval No. 2022NL-CAMT-014).
Informed consent statement: The committee exempted patients from informed consent because it was a retrospective cohort study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Dataset available from the corresponding author at chinalts@njucm.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Sheng Ling, PhD, Professor, Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210029, Jiangsu Province, China. chinalts2024@163.com
Received: August 16, 2024
Revised: December 11, 2024
Accepted: February 10, 2025
Published online: March 14, 2025
Processing time: 193 Days and 14.9 Hours
Core Tip

Core Tip: This retrospective cohort study included 160 patients with rectal neuroendocrine neoplasms who underwent endoscopic full-thickness resection or endoscopic submucosal dissection. Despite similar procedural durations and costs, endoscopic full-thickness resection (EFTR) achieved a 100% complete resection rate, a significant improvement compared to endoscopic submucosal dissection. Additionally, EFTR demonstrated a one-day longer hospital stay with no complications observed. This study indicates EFTR’s potential as a viable alternative for small, deeply infiltrating rectal neuroendocrine neoplasms, highlighting the importance of vertical resection depth for complete tumor eradication.