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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2025; 31(1): 99987
Published online Jan 7, 2025. doi: 10.3748/wjg.v31.i1.99987
Published online Jan 7, 2025. doi: 10.3748/wjg.v31.i1.99987
Gut-liver axis in sepsis-associated liver injury: Epidemiology, challenges and clinical practice
Fabiana Andréa Moura, College of Nutrition, Federal University of Alagoas, Maceio 57072-970, Alagoas, Brazil
Fabiana Andréa Moura, Aryana Isabelle de Almeida Neves Siqueira, College of Medicine, Federal University of Alagoas, Maceio 57072-970, Alagoas, Brazil
Co-first authors: Fabiana Andréa Moura and Aryana Isabelle de Almeida Neves Siqueira.
Author contributions: Moura FA and Siqueira AIAN contributed equally in the conceptualization, data curation, methodology, investigation, original draft preparation, reviewing and editing, they are the co-first authors of this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabiana Andréa Moura, Professor, College of Nutrition, Federal University of Alagoas, Avenue Lourival Melo Mota, S/N, Tabuleiro do Martins, Maceio 57072-970, Alagoas, Brazil. fabiana.moura@fanut.ufal.br
Received: August 4, 2024
Revised: October 15, 2024
Accepted: November 13, 2024
Published online: January 7, 2025
Processing time: 126 Days and 18.8 Hours
Revised: October 15, 2024
Accepted: November 13, 2024
Published online: January 7, 2025
Processing time: 126 Days and 18.8 Hours
Core Tip
Core Tip: Liver-gut axis balance, with dysbiosis, oxidative stress and pro-inflammatory activity control, is linked to sepsis-associated liver injury onset and progression. Therefore, the search for therapeutics targeting these metabolic pathways should be carried out through well-designed clinical trials in order to find ways to support effective clinical treatments.