Ping Zhang, Ying Zhu, Pu Chen, Tong Zhou, Zhe-Yi Han, Jun Xiao, Jian-Feng Ma, Wen Ma, Peng Zang, Ying Chen
Ping Zhang, Ying Zhu, Tong Zhou, Graduate School, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Pu Chen, Peng Zang, Key Laboratory of Aerospace Nutrition and Food Engineering, China Astronaut Research and Training Center, Beijing 100094, China
Zhe-Yi Han, Jian-Feng Ma, Wen Ma, Ying Chen, Department of Gastroenterology, The Air Force Medical Center, Beijing 100142, China
Jun Xiao, Department of Blood Transfusion, Air Force Medical Center, Beijing 100142, China
Co-first authors: Ping Zhang and Ying Zhu.
Co-corresponding authors: Peng Zang and Ying Chen.
Author contributions: Zhang P drafted the manuscript and conducted experiments on animal feeding, establishment of animal models, sampling, Western blotting, RT-qPCR, 16SrRNA sequencing, etc.; Zhu Y assisted in animal sampling, model building, and 16SrRNA experiments; Chen P and Han ZY assisted in the methodology and validation of this study; Zhou T, Ma JF and Ma W participated in the supervision of the writing of this paper; Xiao J assisted in the data statistics and verification of this study; Both Zang P and Chen Y have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Zang P designed and supervised the whole process of the project. He provided guidance on the simulated microgravity model. Chen Y supervised the experiments, reanalysis and interpretation of the data, drew graphs, revised the manuscript, and provided feedback on the complete manuscript. The cooperation between Zang P and Chen Y was essential for the publication of this manuscript.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (Approval Number: ACC-IACUC-2021-014).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data is available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Ying Chen, PhD, Associate Professor, Deputy Director, Occupational Physician, Department of Gastroenterology, The Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing 100142, China.
cy20020910@163.com
Received: April 29, 2024
Revised: September 5, 2024
Accepted: October 12, 2024
Published online: January 7, 2025
Processing time: 224 Days and 3.6 Hours
