Eiamkulbutr S, Tubjareon C, Sanpavat A, Phewplung T, Srisan N, Sintusek P. Diseases of bile duct in children. World J Gastroenterol 2024; 30(9): 1043-1072 [PMID: 38577180 DOI: 10.3748/wjg.v30.i9.1043]
Corresponding Author of This Article
Palittiya Sintusek, MD, PhD, Associate Professor, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology, Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 Rama IV, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Sutha Eiamkulbutr, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand
Chomchanat Tubjareon, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand
Anapat Sanpavat, Department of Pathology, Chulalongkorn University, Bangkok 10330, Thailand
Teerasak Phewplung, Department of Radiology, Chulalongkorn University, Bangkok 10330, Thailand
Nimmita Srisan, Department of Surgery, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand
Palittiya Sintusek, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology, Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, Thailand
Co-first authors: Sutha Eiamkulbutr and Chomchanat Tubjareon.
Author contributions: Eiamkulbutr S, Tubjareon C, and Sintusek P contributed to conception of the study, and wrote the manuscript; Phewplung T provided radiology pictures of patients; Sanpavat A provided histopathology pictures of patients; Sintusek P made critical revisions related to the intellectual content of the manuscript; and all authors read and approved the final version of the manuscript.
Supported byRatchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, RA-MF-18/66.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Palittiya Sintusek, MD, PhD, Associate Professor, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology, Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 Rama IV, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th
Received: October 19, 2023 Peer-review started: October 19, 2023 First decision: December 6, 2023 Revised: December 26, 2023 Accepted: February 4, 2024 Article in press: February 4, 2024 Published online: March 7, 2024 Processing time: 138 Days and 21.2 Hours
Core Tip
Core Tip: Bile duct diseases are rare conditions in children but are mostly pathologic and require timely investigations and management. Biliary atresia (BA) is a common cause of biliary cirrhosis, and affected children with delayed diagnosis require liver transplantation. Early detection of BA using stool color charts or proposed biomarkers has been integrated into the management of infants with cholestasis in many countries. Extrahepatic biliary obstruction caused by stones and choledochal cysts can be easily diagnosed by abdominal ultrasonography and treated by surgical resection. Nowadays, genetic analysis plays a vital role in many bile duct diseases, such as Alagille syndrome. In addition, advanced endoscopic management can improve treatment outcomes and is less invasive than conventional surgical therapy.
