Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-on-chronic liver failure
Yu Zhang, Xiao-Ling Tian, Jie-Qun Li, Dong-Sheng Wu, Qiang Li, Bin Chen
Yu Zhang, Xiao-Ling Tian, Bin Chen, Department of Hepatology, Institute of Hepatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, Hunan Province, China
Jie-Qun Li, Qiang Li, Department of Liver Transplant, Transplant Medical Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Dong-Sheng Wu, Department of Surgery, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, Hunan Province, China
Author contributions: Zhang Y and Tian XL performed experiments, analysed data and wrote the paper; Wu DS and Li Q performed experiments and analysed data; Li JQ and Chen B designed experiments, performed experiments and edited the paper.
Supported by the Domestic First-class Construction Disciplines of the Hunan University of Chinese Medicine; Postgraduate Research Innovation Program of Hunan Province, No. CX20220771; and Clinical MedTech Innovation Project of Hunan Province, No. 2021SK51415.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the First Hospital of Hunan University of Chinese Medicine (No. HN-LL-SWST-15), and written informed consent was obtained from all participants.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest that pertain to this work.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Bin Chen, PhD, Chief Physician, Department of Hepatology, Institute of Hepatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, No. 95 Middle Shaoshan Road, Yuhua District, Changsha 410021, Hunan Province, China.
chenbin0410@126.com
Received: October 8, 2023
Peer-review started: October 8, 2023
First decision: December 8, 2023
Revised: December 15, 2023
Accepted: January 23, 2024
Article in press: January 23, 2024
Published online: February 28, 2024
Processing time: 141 Days and 10.7 Hours
