Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2024; 30(7): 652-662
Published online Feb 21, 2024. doi: 10.3748/wjg.v30.i7.652
Recent advances in age-related metabolic dysfunction-associated steatotic liver disease
Qian-Jun He, Yi-Fei Li, Ling-Tong Zhao, Chun-Tong Lin, Chun-Yan Yu, Dan Wang
Qian-Jun He, Ling-Tong Zhao, Chun-Tong Lin, Chun-Yan Yu, Dan Wang, College of Basic Medicine, Beihua University, Jilin 132013, Jilin Province, China
Yi-Fei Li, Department of Traumatic Surgery, Jilin Central Hospital, Jilin 132001, Jilin Province, China
Author contributions: All authors performed the literature review and wrote the manuscript; He QJ drew and modified the illustrations; Li YF, Yu CY, and Wang D critically reviewed and revised the manuscript.
Supported by Jilin Provincial Department of science and Technology, No. YDZJ202301ZYTS112 and No. YDZJ202101ZYTS090; and Jilin Provincial Health and Family Planning Commission, No. 2021JC084.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Dan Wang, PhD, Professor, College of Basic Medicine, Beihua University, No. 3999 Binjiangdonglu, Jilin 132013, Jilin Province, China.
Received: November 12, 2023
Peer-review started: November 12, 2023
First decision: December 25, 2023
Revised: December 30, 2023
Accepted: January 22, 2024
Article in press: January 22, 2024
Published online: February 21, 2024
Core Tip

Core Tip: Aging is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD). We will focus on the main features of age-related MASLD, the mechanisms by which age-related factors, such as oxidative stress, autophagy, mitochondrial homeostasis, bile acid metabolism and bacterial dysbiosis induce MASLD, as well as the study of related therapeutic targets.