Priego-Parra BA, Remes-Troche JM. Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis. World J Gastroenterol 2024; 30(48): 5104-5110 [DOI: 10.3748/wjg.v30.i48.5104]
Corresponding Author of This Article
Bryan Adrian Priego-Parra, MD, PhD, Research Scientist, Digestive Physiology and Gastrointestinal Motility Laboratory, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Col. Centro, Veracruz 91700, Mexico. bryanpriegop@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 28, 2024; 30(48): 5104-5110 Published online Dec 28, 2024. doi: 10.3748/wjg.v30.i48.5104
Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis
Bryan Adrian Priego-Parra, Jose Maria Remes-Troche
Bryan Adrian Priego-Parra, Jose Maria Remes-Troche, Digestive Physiology and Gastrointestinal Motility Laboratory, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz 91700, Mexico
Author contributions: Priego-Parra BA and Remes-Troche JM contributed equally to the overall concept, writing, editing, and manuscript review; All authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bryan Adrian Priego-Parra, MD, PhD, Research Scientist, Digestive Physiology and Gastrointestinal Motility Laboratory, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Col. Centro, Veracruz 91700, Mexico. bryanpriegop@gmail.com
Received: August 6, 2024 Revised: October 23, 2024 Accepted: November 4, 2024 Published online: December 28, 2024 Processing time: 114 Days and 20.2 Hours
Core Tip
Core Tip: Gastrointestinal cancer and depression are intricately linked in a complex, bidirectional relationship, likely mediated by the microbiota-gut-brain axis through partially understood mechanisms. Chronic inflammation, microbiome alterations, and disruptions to intestinal and blood-brain barriers are pivotal in this interaction. Depression may emerge as a consequence of cancer diagnosis and treatment, while also accelerating cancer progression through neuroendocrine and inflammatory pathways. Early psychological assessments, combined with interventions, such as cognitive-behavioral therapy and microbiota-based therapies, can optimize clinical outcomes, enhance treatment adherence, and improve quality of life. Tailored, culturally sensitive strategies are crucial for advancing precision medicine.
