Tong HX, Ye Y. Insights and future directions in studying intestinal microbiota post-transjugular intrahepatic portosystemic shunt for hepatitis B virus-related portal hypertension. World J Gastroenterol 2024; 30(45): 4855-4858 [PMID: 39649549 DOI: 10.3748/wjg.v30.i45.4855]
Corresponding Author of This Article
Yang Ye, PhD, Research Assistant, Department of Traditional Chinese Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. yeyang89@bjmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 7, 2024; 30(45): 4855-4858 Published online Dec 7, 2024. doi: 10.3748/wjg.v30.i45.4855
Insights and future directions in studying intestinal microbiota post-transjugular intrahepatic portosystemic shunt for hepatitis B virus-related portal hypertension
Hong-Xuan Tong, Yang Ye
Hong-Xuan Tong, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Yang Ye, Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing 100191, China
Author contributions: Tong HX wrote the first draft of the manuscript; Ye Y conceived, reviewed, and revised this paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Ye, PhD, Research Assistant, Department of Traditional Chinese Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. yeyang89@bjmu.edu.cn
Received: August 27, 2024 Revised: September 27, 2024 Accepted: October 29, 2024 Published online: December 7, 2024 Processing time: 79 Days and 1.7 Hours
Core Tip
Core Tip: Hepatitis B virus (HBV) infection promotes cirrhosis in China, causing changes in the gut microbiota (GM) in patients with portal hypertension (PH) GM linked to hepatic encephalopathy (HE). Although a transjugular intrahepatic portosystemic shunt (TIPS) is used to treat PH complications, postoperative HE persists. A recent study explored GM dynamics in patients with HBV-PH post-TIPS and found higher GM synergism in patients without HE than that in those with HE, suggesting it may predict post-TIPS HE risk. However, limitations, such as small sample size, short follow-up, single fecal sampling, and lack of comprehensive analysis of the flora-HBV clinical interplay exist. Future research should prioritize addressing these issues to validate our findings and assess personalized microbiome therapies for post-TIPS HE.
