Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2024; 30(45): 4839-4843
Published online Dec 7, 2024. doi: 10.3748/wjg.v30.i45.4839
Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora
Shuang Han, Rui-Hua Li, Peng Gao
Shuang Han, Rui-Hua Li, Peng Gao, Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Co-first authors: Shuang Han and Rui-Hua Li.
Author contributions: Han S and Li RH contributed to the writing, and editing of the manuscript, illustrations, and literature review; Gao P designed the overall manuscript concept and outline, read and approved the final manuscript; Li RH contributed to the manuscript discussion and design.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Gao, PhD, Executive Director, Professor, Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116023, Liaoning Province, China. gaop@dmu.edu.cn
Received: July 29, 2024
Revised: September 15, 2024
Accepted: October 29, 2024
Published online: December 7, 2024
Processing time: 107 Days and 8.7 Hours
Core Tip

Core Tip: In this article, we comment on Liu et al’s article about intragastric administration of leech total protein could modulate gut microbiota and alleviate hyperuricemia. We speculated that the digestive peptides either generated by the gut flora or by the host digestive system might contribute to the gut microbiota reshaping. Specifically, the study implied that gut microbiota contains many unexplored targets with different therapeutic potentials. If a drug target is developed based on the gut microbiota, it will circumvent the unwanted effects of direct human target utilization. This drug target development notion change will revolutionize the traditional disease-treating paradigm.