Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2024; 30(44): 4697-4708
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4697
Correlation of dynamic contrast-enhanced ultrasonography and the Ki-67 labelling index in pancreatic ductal adenocarcinoma
Xiao-Jing Lin, Shu Zhu, Dan Wang, Jing-Yuan Chen, Su-Xian Wei, Shi-Yun Chen, Hong-Chang Luo
Xiao-Jing Lin, Shu Zhu, Dan Wang, Jing-Yuan Chen, Su-Xian Wei, Shi-Yun Chen, Hong-Chang Luo, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Lin XJ, Zhu S, Wang D, Chen JY, Wei SX, Chen SY and Luo HC designed the research study; Lin XJ, Zhu S, Wang D and Luo HC performed the research; Lin XJ, Chen JY, Wei SX and Chen SY analyzed the data; Lin XJ, Zhu S, Wang D, Chen JY and Luo HC wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. TJ-IRB202402131.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Chang Luo, PhD, Director, Doctor, Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. hongchangluo@qq.com
Received: May 20, 2024
Revised: September 22, 2024
Accepted: October 23, 2024
Published online: November 28, 2024
Processing time: 175 Days and 17 Hours
Core Tip

Core Tip: The Ki-67 labelling index reflects the proliferation of tumor cell and it can only be obtained using puncture biopsy or surgical resection. Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and aggressive tumor. Few studies on preoperative prediction of Ki-67 expression in PDAC using dynamic contrast-enhanced ultrasonography (DCE-US) have been conducted. Our results demonstrate that DCE-US helps noninvasively predict Ki-67 expression preoperatively in PDAC and it is valuable for surgeons to make clinical treatment program and assess prognosis.