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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2024; 30(44): 4689-4696
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4689
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4689
Hypoxia-related bioinformatic signatures associated with prognosis and tumor microenvironment of pancreatic cancer: Current status, concerns, and future perspectives
Dong-Ming Li, Xue-Yuan Cao, Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Jing Jiang, Department of Clinical Epidemiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiang J and Li DM designed the overall concept and outline of the manuscript; Cao XY contributed to the discussion and design of the manuscript; Li DM and Jiang J contributed to the writing and editing of the manuscript, illustrations, and review of the literature. All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82373664; and Scientific and Technological Development Program of Jilin Province, No. 20240402015GH.
Conflict-of-interest statement: The authors declare that they have no competing interests, and all authors confirm its accuracy.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Jiang, MD, PhD, Professor, Department of Clinical Epidemiology, The First Hospital of Jilin University, No. 1 Xinmin Avenue, Chaoyang District, Changchun 130021, Jilin Province, China. jiangjing19702000@jlu.edu.cn
Received: September 18, 2024
Revised: October 25, 2024
Accepted: November 4, 2024
Published online: November 28, 2024
Processing time: 54 Days and 15.5 Hours
Revised: October 25, 2024
Accepted: November 4, 2024
Published online: November 28, 2024
Processing time: 54 Days and 15.5 Hours
Core Tip
Core Tip: Currently, hypoxia-related bioinformatic models for pancreatic cancer (PC) primarily evaluate their value for prognosis, tumor microenvironment, and antitumor drug screening. However, these studies did not identify a prognostic model with an optimal predictive performance for PC. Moreover, findings based on bioinformatic analyses may not be completely reliable; thus, more experimental evidence is required. With the integration of multiomics data, the emergence of deep learning, and the application of high-quality experimental programs, the limitations of these models can be overcome and further application in clinical practice may be recommended in the future.