Portocaval shunts' role in gut microbiota and hepatic encephalopathy: The gut-to-brain pathway

doi:10.3748/wjg.v30.i43.4672

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Nov 21, 2024 (publication date) through Dec 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2024; 30(43): 4672-4676
Published online Nov 21, 2024. doi: 10.3748/wjg.v30.i43.4672

Portocaval shunts' role in gut microbiota and hepatic encephalopathy: The gut-to-brain pathway

Aysun Yakut

Aysun Yakut, Department of Gastroenterology, Istanbul Medipol University Sefakoy Health Practice Research Center, İstanbul 38000, Türkiye

Author contributions: Yakut A designed the overall concept and outline of the manuscript, wrote and edited the manuscript, and performed the literature review.

Conflict-of-interest statement: The author declares that she has no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Aysun Yakut, MD, Doctor, Department of Gastroenterology, Istanbul Medipol University Sefakoy Health Practice Research Center, Tevfikbey District Maslak Cesme Street Kucukcekmece/Istanbul, İstanbul 38000, Türkiye. aysun.yakut@istanbul.edu.tr

Received: August 13, 2024
Revised: September 11, 2024
Accepted: October 9, 2024
Published online: November 21, 2024
Processing time: 78 Days and 14.8 Hours

Core Tip

Core Tip: The gut microbiota (GM) has evolved with the host and has become an integral part of the human body. The GM is highly dynamic and changes depending on the person's diseases, diet, habits, living area, water sources and many other factors. Changes in GM abundance can affect some basic immunological, metabolic, structural and neurological functions of the human body. Therefore, the GM has important effects on both the physical and mental health of an individual. In this beautiful study by Zhao et al examining GM changes after trans-jugular intrahepatic portosystemic shunt, the effect of the dynamic process in GM and its relationship with hepatic encephalopathy are beautifully described.