Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice

doi:10.3748/wjg.v30.i41.4514

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Nov 7, 2024 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2024; 30(41): 4514-4517
Published online Nov 7, 2024. doi: 10.3748/wjg.v30.i41.4514

Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice

Jin Wang, Yao Meng, Zhi-Guo Guo

Jin Wang, Yao Meng, Zhi-Guo Guo, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, Suzhou 234000, Anhui Province, China

Author contributions: Wang J and Meng Y were responsible for writing original draft preparation; Guo ZG was responsible for writing review and editing; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Zhi-Guo Guo, MD, Chief Physician, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, No. 616 Bianyangsan Road, Suzhou 234000, Anhui Province, China. zhigg0268@sina.com

Received: August 27, 2024
Revised: September 23, 2024
Accepted: October 8, 2024
Published online: November 7, 2024
Processing time: 57 Days and 13.6 Hours

Core Tip

Core Tip: Mesenteric adipose tissue and creeping fat (CrF) may play a potential role in Crohn's disease (CD) progression, providing new insights and promising avenues for therapeutic intervention. Fecal microbiota transplantation (FMT) from healthy donors may partially mitigate intestinal inflammatory infiltration, improve intestinal permeability, enhance barrier function, and reduce systemic inflammation in patients with CD. Conversely, FMT from CD patients exacerbates inflammatory changes and contributes to intestinal wall fibrosis. In the present study, we found that the gut microbiota played a multifaceted role, mediating the properties of CrF and influencing the inflammatory and fibrotic phenotypes associated with CD.