Copyright
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2024; 30(40): 4339-4353
Published online Oct 28, 2024. doi: 10.3748/wjg.v30.i40.4339
Published online Oct 28, 2024. doi: 10.3748/wjg.v30.i40.4339
Advancing diabetes management: Exploring pancreatic beta-cell restoration’s potential and challenges
Mona Mohamed Ibrahim Abdalla, Department of Human Biology, School of Medicine, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
Author contributions: Abdalla MMI conducted the research and wrote the manuscript.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mona Mohamed Ibrahim Abdalla, MSc, PhD, Senior Lecturer, Department of Human Biology, School of Medicine, International Medical University, No. 126, Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia. monamohamed@imu.edu.my
Received: July 27, 2024
Revised: September 5, 2024
Accepted: September 24, 2024
Published online: October 28, 2024
Processing time: 80 Days and 10.3 Hours
Revised: September 5, 2024
Accepted: September 24, 2024
Published online: October 28, 2024
Processing time: 80 Days and 10.3 Hours
Core Tip
Core Tip: Diabetes, a disease of uncontrolled blood sugar, arises from the loss or dysfunction of insulin-producing beta cells within the pancreas. While traditional management focuses on external insulin, cutting-edge research explores restoring these beta cells. Strategies include stem cell therapy, gene editing, and discovering molecules that promote beta cell growth. However, ensuring safety, overcoming biological complexities, and navigating the ethics of stem cell use present challenges. Through continued research, funding, and a patient-centered approach, beta-cell restoration offers the potential to move diabetes care from management to a possible cure.