Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2024; 30(39): 4281-4294
Published online Oct 21, 2024. doi: 10.3748/wjg.v30.i39.4281
Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer
Jing-Zhao Zhang, Zhi-Wei Zhang, Xin-Yi Guo, Deng-Sheng Zhu, Xiao-Rui Huang, Ming Cai, Tong Guo, Ya-Hong Yu
Jing-Zhao Zhang, Zhi-Wei Zhang, Xin-Yi Guo, Deng-Sheng Zhu, Xiao-Rui Huang, Ming Cai, Tong Guo, Ya-Hong Yu, Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China
Co-first authors: Jing-Zhao Zhang and Zhi-Wei Zhang.
Co-corresponding authors: Tong Guo and Ya-Hong Yu.
Author contributions: Zhang JZ and Zhang ZW have contributed equally to this work; Zhang JZ was responsible for to data curation, conceptualization, methodology, and writing the original draft; Zhang ZW wrote the original draft and performed formal data analysis; Guo XY and Zhu DS completed case collection, follow-up and preliminary data compilation; Huang XR revised the manuscript and provided clinical advice. Guo T and Yu YH were contributed equally to supervision, funding acquisition, writing-review and editing. First, the corresponding author, as the primary individual responsible for the article, oversees the selection of the topic, research design, and content review. Both Professor Yu YH and Dr Guo T shared these responsibilities throughout the study's implementation. They jointly agreed on the topic selection, collaboratively formulated the research plan, and provided equally significant support in executing the plan. Second, upon completion of the manuscript, both authors contributed unique insights regarding the depth of the content and the rigor of the conclusions. They collaboratively assisted in the correction and editing processes and finalized the preparation of the relevant submission materials. Their contributions were equivalent in importance. Third, during the ethical review of this article, both authors jointly prepared the necessary materials, demonstrating the ethical soundness of this study, which successfully passed the ethical approval process. This collaboration ensured the smooth progression of the research. Fourth, both authors provided equally crucial assistance in securing funding for this study. Given the substantial contributions made by both individuals to this article, they are designated as co-corresponding authors.
Institutional review board statement: The study was approved by the ethics committee of the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent statement: The acquisition and use of these clinical data were approved by the Institutional Review Board. After review by the ethics committee, a waiver of informed consent was granted for this subject.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Hong Yu, MD, Professor, Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan 430000, Hubei Province, China. yuyahong615@sina.com
Received: May 9, 2024
Revised: September 13, 2024
Accepted: September 20, 2024
Published online: October 21, 2024
Processing time: 155 Days and 13.1 Hours
Core Tip

Core Tip: Ampullary cancer research is crucial due to its increasing incidence. This study differentiates ampullary cancer types based on its primary site, showing that ampulla of Vater cancer (AVC) patients have shorter overall survival than duodenal papilla cancer (DPC) patients. Prognosis for AVC may be affected by serum albumin, total bilirubin, and positive lymph nodes. For DPC patients, age, tumor size, and lymph node positivity are linked to worse outcomes, with adjuvant therapy potentially improving prognosis. The findings offer doctors valuable insights for managing both cancer types.