Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2024; 30(38): 4232-4238
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4232
Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma: A case report
Yi-Fan Jia, Fei-Fan Chen, Li Yang, Yun-Xia Ye, Yi-Zhu Gao, Wen-Yan Zhang, Jin-Lin Yang
Yi-Fan Jia, Fei-Fan Chen, Li Yang, Jin-Lin Yang, Department of Gastroenterology and Hepatology, University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yun-Xia Ye, Wen-Yan Zhang, Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yi-Zhu Gao, Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Co-first authors: Yi-Fan Jia and Fei-Fan Chen.
Co-corresponding authors: Wen-Yan Zhang and Jin-Lin Yang.
Author contributions: Jia YF and Chen FF contributed equally to manuscript writing and editing, and data collection; they make the equal contribution; Yang L, Ye YX, and Gao YZ contributed to conceptualization and supervision; Yang JL and Zhang WY contributed equally to revise the article and supervision; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82173253.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Lin Yang, MD, Professor, Department of Gastroenterology and Hepatology, University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, No. 37 Guoxue Road, Wuhou District, Chengdu 610041, Sichuan Province, China. yangjinlin@wchscu.cn
Received: March 18, 2024
Revised: September 10, 2024
Accepted: September 13, 2024
Published online: October 14, 2024
Processing time: 194 Days and 19.3 Hours
Core Tip

Core Tip: This paper reports a rare case of an early composite tumor involving the simultaneous occurrence of gastric signet-ring cell carcinoma (SRCC) and mucosa-associated lymphoid tissue lymphoma. A “composite tumor” is a unique phenomenon that combines two distinct tumor types into a single lesion without clear borders. When signet-ring cells are present in gastric B-cell lymphoma, it is crucial to carefully distinguish between lymphoma-associated signet-ring cell changes and gastric SRCCs. The former exhibits inconspicuous epithelial cell atypia and is mostly negative for p53 on immunohistochemistry, with positive E-cadherin expression, whereas the latter exhibits the opposite pattern.