Systematic Reviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2024; 30(38): 4221-4231
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4221
Survival outcomes in early-onset oesophageal adenocarcinoma patients: A systematic review and meta-analyses
Ashleigh Russell, Shauna Mitchell, Richard C Turkington, Helen G Coleman
Ashleigh Russell, Helen G Coleman, Centre for Public Health, Queen's University Belfast, Belfast BT12 6BA, United Kingdom
Shauna Mitchell, Richard C Turkington, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT7 1NN, United Kingdom
Author contributions: Mitchell S, Coleman HG and Turkington RC designed the research; Mitchell S, Coleman HG and Turkington RC performed the research; All authors contributed to data analysis and interpretation, and writing of the paper.
Conflict-of-interest statement: Payment or honoraria for lectures, presentations, or educational events: Dr. Ashleigh Russell (née Hamilton): Bristol-Myers Squibb (independent Speaker - paid directly by BMS).
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2020 Checklist, and the manuscript was prepared and revised according to the PRISMA 2020 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ashleigh Russell, MBChB, MRCP, PhD, Academic Fellow, Staff Physician, Centre for Public Health, Queen's University Belfast, ICS-B Building, Royal Victoria Hospital Site, Grosvenor Road, Belfast BT12 6BA, United Kingdom. a.russell@qub.ac.uk
Received: January 28, 2024
Revised: July 4, 2024
Accepted: September 20, 2024
Published online: October 14, 2024
Processing time: 245 Days and 9.3 Hours
Core Tip

Core Tip: In this systematic review, we investigated survival outcomes in early-onset oesophageal adenocarcinoma (OAC) (< 50 years) compared to older age groups. Eleven studies were included. A narrative review of median and mean survival demonstrated conflicting results. Meta-analyses of 5-year survival and risk of death demonstrated no significant difference in survival between younger and older OAC patients. Current evidence in this area has limitations, and up-to-date population-based research is required.