Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2024; 30(38): 4175-4193
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4175
Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer
Tian-Qi Jiang, Hao Wang, Wang-XinJun Cheng, Chuan Xie
Tian-Qi Jiang, Hao Wang, Chuan Xie, Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Tian-Qi Jiang, Hao Wang, The First Clinical Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Wang-XinJun Cheng, Queen Mary College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Co-first authors: Tian-Qi Jiang and Hao Wang.
Author contributions: Xie C conceived and designed the study; Jiang TQ, Wang H, and Cheng WX edited the manuscript; All the authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82100599 and No. 81960112; the Jiangxi Provincial Department of Scientific introductions, No. 20212ACB216003 and No. 20242BAB26122; the Science and Technology Plan of Jiangxi Provincial Administration of Traditional Chinese Medicine, No. 2023Z021; and the Young Talents Project of Jiangxi Provincial Academic and Technical Leaders Training Program for Major Disciplines, No. 20204BCJ23022.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chuan Xie, MD, Chief Doctor, Teacher, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China. xcsghhz@ncu.edu.cn
Received: June 4, 2024
Revised: August 29, 2024
Accepted: September 12, 2024
Published online: October 14, 2024
Processing time: 117 Days and 4.4 Hours
Core Tip

Core Tip: This review summarizes the interactions of N6-methyladenosine (m6A) modification in colorectal cancer (CRC) with a variety of the tumour microenvironment factors such as metabolism, hypoxia, inflammation, and immunity and supports the idea that intestinal flora can influence the progression of CRC by regulating the level of m6A modification. Additionally, this review also summarizes the clinical applications of m6A modifications in CRC and suggests possible future research directions.