Effects and mechanisms of Helicobacter pylori infection on the occurrence of extra-gastric tumors

doi:10.3748/wjg.v30.i37.4090

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Oct 7, 2024 (publication date) through Sep 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2024; 30(37): 4090-4103
Published online Oct 7, 2024. doi: 10.3748/wjg.v30.i37.4090

Effects and mechanisms of Helicobacter pylori infection on the occurrence of extra-gastric tumors

Shi-Qing Zhao, Hui-Ling Zheng, Xiao-Tian Zhong, Zi-Ye Wang, Yi Su, Yan-Yan Shi

Shi-Qing Zhao, Xiao-Tian Zhong, Zi-Ye Wang, Yi Su, Yan-Yan Shi, Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China

Shi-Qing Zhao, Xiao-Tian Zhong, Zi-Ye Wang, Yi Su, Health Science Center, Peking University, Beijing 100191, China

Hui-Ling Zheng, Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China

Co-first authors: Shi-Qing Zhao and Hui-Ling Zheng.

Author contributions: Zhao SQ and Zheng HL contributed to drafting the manuscript and making charts; Shi YY was responsible for designing and revising this review; Zhong XT, Wang ZY, and Su Y provided suggestions and contributed to discussion; All authors have read and approved the article.

Supported by Beijing Natural Science Foundation, No. J230002.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Yan-Yan Shi, MD, Professor, Research Center of Clinical Epidemiology, Peking University Third Hospital, No. 49 Garden North Road, Haidian District, Beijing 100191, China. shiyanyan@bjmu.edu.cn

Received: April 9, 2024
Revised: August 23, 2024
Accepted: September 12, 2024
Published online: October 7, 2024
Processing time: 170 Days and 7.2 Hours

Core Tip

Core Tip: Apart from gastric diseases, several studies have revealed an association between Helicobacter pylori (H. pylori) and extra-gastric diseases, including cancers. Inflammation, systemic immune responses, microbiome disorders, and hypergastrinemia caused by H. pylori may change the tumor microenvironment and eventually contribute to extra-gastric carcinogenesis. However, the research in this field remains controversial. We summarized the effects of H. pylori infection on the occurrence of extra-gastric tumors and their possible mechanisms, hoping to provide insights for clinical treatment and management of H. pylori-related extra-gastric tumors, as well as help improve prognosis.