Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2024; 30(36): 4057-4070
Published online Sep 28, 2024. doi: 10.3748/wjg.v30.i36.4057
Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment
Fan Yang, Na Jiang, Xiao-Yu Li, Xing-Si Qi, Zi-Bin Tian, Ying-Jie Guo
Fan Yang, Na Jiang, Xiao-Yu Li, Xing-Si Qi, Zi-Bin Tian, Ying-Jie Guo, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Co-corresponding authors: Zi-Bin Tian and Ying-Jie Guo.
Author contributions: Yang F, Guo YJ, and Tian ZB designed the study; Yang F, Guo YJ, Tian ZB and Jiang N performed the experiments, and acquired and analyzed the data; Yang F, Guo YJ, Li XY and Qi XS prepared the figures and tables; Yang F, Guo YJ, and Tian ZB reviewed and edited the manuscript. All authors reviewed and approved the final version of the article. Guo YJ and Tian ZB are designated as co-corresponding authors due to their nearly equal contributions across various aspects of the project. They played crucial roles at multiple key stages of the study, including research conception, methodology design, data analysis, and manuscript preparation. Throughout the research process, they jointly managed communication with the journal and addressed related issues, ensuring the smooth progress and accurate representation of the research findings. Designating them as co-corresponding authors not only reflects their shared commitment to the work but also ensures that their contributions are equally recognized and valued. The designation of co-corresponding authors highlights the collaborative spirit and high professional standards within the team and strengthens the scientific rigor and integrity of the paper.
Supported by National Natural Science Foundation of China, No. 82100581.
Institutional review board statement: The manuscript did not involve human participants, animal subjects, or any other materials that require ethical review.
Institutional animal care and use committee statement: The manuscript did not involve animal subjects.
Conflict-of-interest statement: The authors declare that they have no competing interests, and all authors confirm its accuracy.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at guoyingjie305@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Jie Guo, MD, Doctor, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. guoyingjie305@163.com
Received: July 14, 2024
Revised: August 22, 2024
Accepted: September 5, 2024
Published online: September 28, 2024
Processing time: 67 Days and 14 Hours
Core Tip

Core Tip: In this study, a prognostic model based on the expression levels of the hypoxia-related genes CAPN2, PLAU, and CCNA2 was developed for pancreatic cancer. Compared with traditional methods, the model demonstrated superior predictive accuracy, and the model risk score was strongly correlated with clinical features such as cancer stage and tumor size. The risk score was also significantly associated with chemotherapy drug sensitivity and metabolic pathway activity. These findings highlight the model's potential to enhance personalized treatment selection and improve prognosis.