Game changer: How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis management

doi:10.3748/wjg.v30.i35.3942

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2024; 30(35): 3942-3953
Published online Sep 21, 2024. doi: 10.3748/wjg.v30.i35.3942

Game changer: How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis management

Antonio M Caballero-Mateos, Guillermo Arturo Cañadas-de la Fuente

Antonio M Caballero-Mateos, Department of Gastroenterology and Hepatology, San Cecilio University Hospital, Granada 18014, Spain

Guillermo Arturo Cañadas-de la Fuente, Department of Nursing, Faculty of Health Sciences, University of Granada, Granada 18004, Spain

Author contributions: Caballero-Mateos AM contributed to the conception, design, and drafting of the manuscript; Cañadas-de la Fuente GA contributed to the design and revision of the manuscript.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Antonio M Caballero-Mateos, PhD, Assistant Lecturer, Doctor, Gastroenterology and Hepatology Department, San Cecilio University Hospital, AV conocimiento sn, Granada 18014, Spain. ogy1492@hotmail.com

Received: July 6, 2024
Revised: August 19, 2024
Accepted: August 22, 2024
Published online: September 21, 2024
Processing time: 68 Days and 3.8 Hours

Core Tip

Core Tip: Janus kinase inhibitors such as tofacitinib, filgotinib, and upadacitinib represent a significant advancement in ulcerative colitis (UC) management, offering effective induction and maintenance of remission, especially for patients unresponsive to conventional therapies. Despite potential safety concerns, these agents provide rapid action and the ability to tailor treatment to individual patient needs, marking a paradigm shift in UC treatment strategies.