Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies

doi:10.3748/wjg.v30.i35.3932

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Sep 21, 2024 (publication date) through Sep 13, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2024; 30(35): 3932-3941
Published online Sep 21, 2024. doi: 10.3748/wjg.v30.i35.3932

Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies

Hao-Jie Ge, Xu-Lin Chen

Hao-Jie Ge, Xu-Lin Chen, Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China

Author contributions: Ge HJ wrote the original draft, prepared the figure, and revised the manuscript; Chen XL conducted conceptualization and supervision.

Conflict-of-interest statement: The authors declare no conflict of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xu-Lin Chen, MD, Director, Doctor, Department of Burns, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. okcxl@126.com

Received: March 6, 2024
Revised: August 12, 2024
Accepted: August 26, 2024
Published online: September 21, 2024
Processing time: 190 Days and 8.4 Hours

Core Tip

Core Tip: This editorial provides a comprehensive review of the pathophysiological mechanisms underlying celiac disease and explores emerging therapeutic strategies, including the potential role of Aspergillus niger-derived prolyl endopeptidase. The discussion emphasizes the need for new treatments that address the multifaceted nature of the disease, aiming to improve patient quality of life beyond the limitations of a strict gluten-free diet.