Navigating the autophagic landscape: Epigenetic modulation in gastrointestinal cancer

doi:10.3748/wjg.v30.i31.3628

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Aug 21, 2024 (publication date) through Aug 14, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2024; 30(31): 3628-3634
Published online Aug 21, 2024. doi: 10.3748/wjg.v30.i31.3628

Navigating the autophagic landscape: Epigenetic modulation in gastrointestinal cancer

Davide Ramoni, Federico Carbone, Fabrizio Montecucco

Davide Ramoni, Department of Internal Medicine, University of Genoa, Genoa 16132, Italy

Federico Carbone, Fabrizio Montecucco, Department of Internal Medicine, University of Genoa and IRCSS Policlinico San Martino, Genoa 16132, Italy

Author contributions: Ramoni D performed the conceptualization and writing of the original draft; Carbone F and Montecucco F provided supervision and edited the entire work; All authors have read and approved the final manuscript.

Conflict-of-interest statement: All authors have no conflicts of interest to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fabrizio Montecucco, MD, PhD, Full Professor, Department of Internal Medicine and Medical Specialties, University of Genoa and IRCSS Ospedale Policlinico San Martino, 6 Viale Benedetto XV, Genoa 16132, Italy. fabrizio.montecucco@unige.it

Received: March 20, 2024
Revised: July 18, 2024
Accepted: July 23, 2024
Published online: August 21, 2024
Processing time: 145 Days and 18.5 Hours

Core Tip

Core Tip: Understanding the intricate interplay between autophagy, epigenetics, and non-coding RNA (ncRNA) regulation in gastrointestinal (GI) cancers is crucial for devising effective therapeutic interventions. Autophagy exhibits a dual role in cancer progression, impacting treatment response rates, and its modulation through epigenetic alterations and ncRNA regulation offers promising avenues for targeted therapies. Developing strategies to manipulate autophagy, particularly via epigenetic mechanisms and nanocarrier-based ncRNA delivery systems, holds immense potential to enhance the effectiveness of chemotherapy and improve outcomes in GI malignancies.