SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis
Qing Gu, Huan Xia, Yue-Qiong Song, Jun Duan, Yun Chen, You Zhang, He-Ping Chen, Li Zhang
Qing Gu, Yue-Qiong Song, Jun Duan, Yun Chen, You Zhang, He-Ping Chen, Li Zhang, Department of Elderly Digestive, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu 610072, Sichuan Province, China
Huan Xia, He-Ping Chen, Li Zhang, Geriatrics Research Institute, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Co-first authors: Qing Gu and Huan Xia.
Co-corresponding authors: He-Ping Chen and Li Zhang.
Author contributions: Gu Q and Xia H contributed equally to this work; Chen HP and Zhang L conceived and designed the study and provided administrative support; Gu Q, Xia H and Zhang L performed the experiments and analyzed data; Gu Q, Song YQ, Duan J and Chen HP analyzed and interpreted the data; Xia H, Chen Y, Zhang Y and Zhang L wrote the manuscript; all authors read and approved the final manuscript.
Supported by The Key Research and Development Projects of Sichuan Science and Technology Department, No. 2023YFS0285; and Natural Science Foundation Project of Sichuan Science and Technology Department, No. 2023NSFSC0613.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital.
Institutional animal care and use committee statement: All animal experiments were performed following the approval of the Animal Care and Use Committee of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital [Lunshen (Yan)2022-380].
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Li Zhang, PhD, Doctor, Professor, Department of Elderly Digestive, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, 32 West Section 2, Yihuan Road, Chengdu 610072, Sichuan Province, China. 1262867096@qq.com
Received: August 31, 2023
Peer-review started: August 31, 2023
First decision: October 29, 2023
Revised: November 8, 2023
Accepted: December 18, 2023
Article in press: December 18, 2023
Published online: January 21, 2024
