Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2024; 30(29): 3488-3510
Published online Aug 7, 2024. doi: 10.3748/wjg.v30.i29.3488
Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
Xia Liu, Xing-Qiu Liang, Tian-Cai Lu, Zhe Feng, Min Zhang, Nan-Qing Liao, Feng-Lian Zhang, Bo Wang, Li-Sheng Wang
Xia Liu, Nan-Qing Liao, Feng-Lian Zhang, Bo Wang, Li-Sheng Wang, Medical College, Guangxi University, Nanning 530004, Guangxi Zhuang Autonomous Region, China
Xia Liu, Department of Traditional Chinese Medicine, HIV/AIDS Clinical Treatment Center of Guangxi (Nanning), The Fourth People’s Hospital of Nanning, Nanning 530023, Guangxi Zhuang Autonomous Region, China
Xing-Qiu Liang, Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Tian-Cai Lu, General Manager’s Office, Guangxi Fuxinyi Biological Technology Co. Ltd., Pingnan 537300, Guangxi Zhuang Autonomous Region, China
Zhe Feng, Department of Joint and Sports Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Min Zhang, Department of Gerontology, Nanning Social Welfare Hospital, Nanning 530004, Guangxi Zhuang Autonomous Region, China
Author contributions: Liu X, Liang XQ, Lu TC, and Wang LS designed the research study; Liu X, Liang XQ, and Wang LS performed the research and wrote the original draft; Feng Z, Zhang M, and Wang B conducted the investigations; Liu X, Zhang FL, Wang B, and Wang LS developed the methodologies; Zhang M, Liao NQ, Zhang FL, and Wang LS managed the software used; Lu TC and Wang LS acquired the funding; Lu TC, Feng Z, and Wang LS administered the project and supervised the project; Liu X, Zhang FL, and Wang B validated the results; Liu X and Wang LS reviewed and edited the manuscript. All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82160843.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Attitude of Animal Care & Welfare Committee of Guangxi University (No. GXU-2023-0203).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at lswang@gxu.edu.cn.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Sheng Wang, MD, PhD, Professor, Medical College, Guangxi University, No. 100 Daxue East Road, Nanning 530004, Guangxi Zhuang Autonomous Region, China. lswang@gxu.edu.cn
Received: March 10, 2024
Revised: June 20, 2024
Accepted: July 19, 2024
Published online: August 7, 2024
Processing time: 140 Days and 14.8 Hours
Core Tip

Core Tip: This study reveals the novel therapeutic potential of Poecilobdella manillensis in treating hyperuricemia (HUA) through a dual mechanism: The direct modulation of uric acid levels and restoration of renal and intestinal barriers. Importantly, it highlights the role of proteins in Poecilobdella manillensis in rectifying gut microbiota dysbiosis and adjusting key metabolic pathways, most notably, sphingolipid and galactose metabolism. These findings highlight the multi-target, multi-channel effects of Poecilobdella manillensis treatment for HUA and provide fundamental data for the clinical use of HUA treatments.