Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease
Aritoshi Koizumi, Kosuke Kaji, Norihisa Nishimura, Shohei Asada, Takuya Matsuda, Misako Tanaka, Nobuyuki Yorioka, Yuki Tsuji, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Aritoshi Koizumi, Kosuke Kaji, Norihisa Nishimura, Shohei Asada, Takuya Matsuda, Misako Tanaka, Nobuyuki Yorioka, Yuki Tsuji, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji, Department of Gastroenterology, Nara Medical University, Kashihara 634-8521, Japan
Author contributions: Koizumi A and Kaji K contributed to the data curation; Koizumi A, Nishimura N, Asada S, Matsuda T, Tanaka M, Yorioka N, and Tsuji Y were involved in the investigation of this manuscript; Koizumi A, Nishimura N, and Kitagawa K participated in the formal analysis; Koizumi A, Kaji K, and Namisaki T contributed to the methodology of this study; Koizumi A prepared the writing-original draft; Kaji K and Yoshiji H took part in the conceptualization and resources of this article; Koizumi A, Akahane T, and Yoshiji H contributed to the supervision of this manuscript; Kaji K participated in the validation; Kaji K and Kitagawa K were involved in the visualization; Kaji K, Nishimura N, Asada S, Matsuda T, Tanaka M, Yorioka N, Tsuji Y, Kitagawa K, Sato S, Namisaki T, Akahane T, and Yoshiji H contributed to the writing-review and editing of this manuscript; Sato S contributed to the software.
Institutional review board statement: The study was reviewed and approved by the Institutional review board of Nara Medical University, Kashihara, Japan (authorization numbers: 13130).
Institutional animal care and use committee statement: All animal experiments were performed in accordance with the Guide for Care and Use of Laboratory Animals of the National Research Council.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Kosuke Kaji, MD, PhD, Chief, Lecturer, Department of Gastroenterology, Nara Medical University, Shijo-cho 840, Kashihara 634-8521, Japan. kajik@naramed-u.ac.jp
Received: February 26, 2024
Revised: May 31, 2024
Accepted: June 20, 2024
Published online: July 28, 2024
Processing time: 148 Days and 18.6 Hours
