Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2024; 30(27): 3290-3303
Published online Jul 21, 2024. doi: 10.3748/wjg.v30.i27.3290
Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients
Pei-Qi Sun, Wen-Min Dong, Yi-Fu Yuan, Qin Cao, Xiao-Yan Chen, Li-Li Guo, Yuan-Ye Jiang
Pei-Qi Sun, Yi-Fu Yuan, Qin Cao, Xiao-Yan Chen, Yuan-Ye Jiang, Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
Wen-Min Dong, Department of Pharmacy, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
Li-Li Guo, Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Co-first authors: Pei-Qi Sun and Wen-Min Dong.
Co-corresponding authors: Li-Li Guo and Yuan-Ye Jiang.
Author contributions: Guo LL and Jiang YY conceived and designed the study; Jiang YY supervised the work, Guo LL contributed to the writing of the revision draft, they are the co-corresponding authors of this manuscript; Sun PQ and Dong WM performed the research, they contributed to this study equally; Sun PQ acquired patient and samples; Dong WM contributed to the writing of the manuscript; Yuan YF, Cao Q, and Chen XY analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Supported by Shanghai Natural Science Foundation, No. 22ZR1455900; Shanghai Putuo District Health System Science and Technology Innovation Project Key Project, No. ptkwws202201; and Shanghai Putuo District Xinglin Excellent Youth Talent Training Program, No. ptxlyq2201.
Institutional review board statement: An ethics review form is available for this study (Approval No: PTEC-A-2018-49-1).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: We consent to data sharing.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4. 0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Ye Jiang, Doctor, Doctor, Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164 Lanxi Road, Shanghai 200062, China. yuanye1014@126. com
Received: January 22, 2024
Revised: May 9, 2024
Accepted: June 6, 2024
Published online: July 21, 2024
Processing time: 170 Days and 23.3 Hours
Core Tip

Core Tip: This study targeted the serum metabolomics of healthy individuals and metabolic-associated fatty liver disease (lean-type MAFLD), screened biomarkers and related metabolic pathways, and conducted targeted quantitative analysis of their specific biomarkers with the aim of providing experimental evidence for the early diagnosis and pathogenesis of lean-type MALFD.