Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2024; 30(27): 3273-3277
Published online Jul 21, 2024. doi: 10.3748/wjg.v30.i27.3273
Novel insights into autophagy in gastrointestinal pathologies, mechanisms in metabolic dysfunction-associated fatty liver disease and acute liver failure
Tsvetelina Velikova, Milena Gulinac
Tsvetelina Velikova, Milena Gulinac, Medical Faculty, Sofia University St Kliment Ohridski, Sofia 1407, Bulgaria
Milena Gulinac, Department of General and Clinical Pathology, Medical University of Plovdiv, Plovdiv 4002, Bulgaria
Author contributions: Velikova T and Gulinac M wrote the paper; Velikova T revised the paper; All authors approved the final version of the manuscript before submission.
Supported by the European Union-NextGenerationEU, through The National Recovery and Resilience Plan of The Republic of Bulgaria, No. BG-RRP-2.004-0008.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Milena Gulinac, MD, PhD, Academic Research, Department of General and Clinical Pathology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, Bulgaria. mgulinac@hotmail.com
Received: March 21, 2024
Revised: May 26, 2024
Accepted: June 24, 2024
Published online: July 21, 2024
Processing time: 111 Days and 18.3 Hours
Core Tip

Core Tip: Exploration of autophagy's role in gastrointestinal (GI) disorders, as well as metabolic dysfunction-associated fatty liver disease (MAFLD) and acute liver failure (ALF), is imperative for advancing diagnostic and treatment strategies in gastroenterological diseases. Despite advancements, understanding autophagy's intricate mechanisms in these conditions remains incomplete. Further research into MAFLD's diagnostic markers and treatment modalities, considering its hepatic steatosis and metabolic dysregulation, is crucial. Elucidating diagnostic and therapeutic approaches for ALF, a severe hepatic dysfunction, is essential. Investigating autophagy's implications in diagnosing and treating GI disorders, MAFLD, and ALF is pivotal for improving patient outcomes.