Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

doi:10.3748/wjg.v30.i26.3229

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Jul 14, 2024 (publication date) through Jul 10, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Jul 14, 2024; 30(26): 3229-3246
Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3229

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

Juan Sun, Jin-Xiu Zhang, Meng-Shi Li, Meng-Bin Qin, Ruo-Xi Cheng, Qing-Ru Wu, Qiu-Ling Chen, Dan Yang, Cun Liao, Shi-Quan Liu, Jie-An Huang

Juan Sun, Jin-Xiu Zhang, Meng-Shi Li, Meng-Bin Qin, Ruo-Xi Cheng, Qing-Ru Wu, Qiu-Ling Chen, Dan Yang, Shi-Quan Liu, Jie-An Huang, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China

Cun Liao, Department of Colorectal & Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Co-first authors: Juan Sun and Jin-Xiu Zhang.

Author contributions: Sun J and Zhang JX contributed equally to this study; Sun J, Zhang JX, and Huang JA developed the original hypothesis, supervised the experimental design, and wrote and revised the manuscript; Sun J, Zhang JX, Li MS, and Qin MB performed in vitro and in vivo experiments; Qin MB, Cheng RX, Wu QR, and Liao C participated in the clinical specimens collection; Sun J, Zhang JX, Chen QL, Yang D, and Liu SQ analyzed the data and performed statistical analysis; and all authors read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 81760516; Natural Science Foundation of Guangxi, China, No. 2019GXNSFAA185030; Self-Financed Scientific Research Projects of Guangxi Zhuang Autonomous Region Health and Family Planning Commission, China, No. Z20181003; and Guangxi Medical University Youth Science Fund Project, China, No. GXMUYSF202221.

Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Guangxi Medical University Institutional Review Board (Approval No. 2022-E335-01).

Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Guangxi Medical University (Protocol No. 202108006).

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jie-An Huang, PhD, Chief Physician, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxue East Road, Xixiangtang District, Nanning 530007, Guangxi Zhuang Autonomous Region, China. hjagxmu@163.com

Received: April 30, 2024
Revised: May 28, 2024
Accepted: June 3, 2024
Published online: July 14, 2024
Processing time: 69 Days and 19.4 Hours

Core Tip

Core Tip: Monopolar spindle-binding protein 3B (MOB3B) functions as a signal transducer and altered MOB3B expression is associated with the development of human cancers. In this study, we investigated the effects of MOB3B in colorectal cancer (CRC). We found that loss of MOB3B expression promoted CRC development and malignant behaviors, suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mechanistic target of rapamycin kinase/autophagy signaling.