Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2024; 30(24): 3086-3105
Published online Jun 28, 2024. doi: 10.3748/wjg.v30.i24.3086
Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori
Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye, Xue-Zhi Zhang
Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye, Xue-Zhi Zhang, Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China
Miao-Miao Lin, Shan-Shan Yang, Qiu-Yue Huang, Guang-Hui Cui, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Hui Ye, Xue-Zhi Zhang, Institute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing 100034, China
Co-corresponding authors: Hui Ye and Xue-Zhi Zhang.
Author contributions: Ye H and Zhang XZ designed the study, provided financial support, and revised the manuscript, making equal contributions to this work as co-corresponding authors; Lin MM performed the experiments, conducted data analysis, and drafted the manuscript; Jia XF, Yang Y, and Shi ZM interpreted the data; Yang SS, Huang QY, and Cui GH corrected the paper; and all authors reviewed/edited the manuscript and approved the final version.
Supported by the National Natural Science Foundation of China, No. 81973615 and No. 82304930; Natural Science Foundation of Beijing, No. 7332323; and Capital’ s Funds for Health Improvement and Research, No. CF2022-2-40711.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Peking University First Hospital (Approval No. 2022Yan130-002).
Conflict-of-interest statement: All the authors declare that they have no competing interest to disclose.
Data sharing statement: The relevant experimental data regarding humans and bacteria are available from the corresponding authors on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Zhi Zhang, MD, PhD, Chief Physician, Professor, Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. zhang.xuezhi@263.net
Received: February 25, 2024
Revised: May 5, 2024
Accepted: May 29, 2024
Published online: June 28, 2024
Processing time: 121 Days and 4.8 Hours
Core Tip

Core Tip:Helicobacter pylori (HP) infection affects over 4.4 billion people worldwide, with its multidrug resistance posing a serious challenge. Twelve strains of HP were isolated in vitro following biopsy during gastroscopy of HP-infected patients, with the most robust biofilm-forming strain of HP being selected to investigate the effect and mechanism of Qingre Huashi decoction (QHD) on drug-resistant HP. QHD has bacteriostatic and bactericidal effects on HP, reduces HP drug-resistance by inhibiting biofilm formation, destroying biofilm structure, inhibiting biofilm-related and efflux pump-related gene expression, enhancing HP metabolism, and activating adenosine monophosphate in HP.