Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2024; 30(24): 3044-3047
Published online Jun 28, 2024. doi: 10.3748/wjg.v30.i24.3044
Aspergillus niger prolyl endopeptidase in celiac disease
Marica Colella, Concetta Cafiero, Raffaele Palmirotta
Marica Colella, Raffaele Palmirotta, Interdisciplinary Department of Medicine, Section of Microbiology and Virology, University of Bari “Aldo Moro”, Bari 70124, Italy
Concetta Cafiero, Area of Molecular Pathology, Anatomic Pathology Unit, Fabrizio Spaziani Hospital, Frosinone 03100, Italy
Author contributions: Palmirotta R, Colella M and Cafiero C contributed to this paper; Palmirotta R designed the overall concept and outline of the manuscript; Palmirotta R and Colella M contributed to the discussion and design of the manuscript; Palmirotta R, Colella M and Cafiero C contributed to the writing, editing the manuscript and review of the literature; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raffaele Palmirotta, MD, PhD, Associate Professor, Senior Researcher, Interdisciplinary Department of Medicine, Section of Microbiology and Virology, University of Bari “Aldo Moro”, P.zza G. Cesare, 11, Bari 70124, Italy. raffaelepalmirotta@gmail.com
Received: March 19, 2024
Revised: May 10, 2024
Accepted: May 27, 2024
Published online: June 28, 2024
Processing time: 98 Days and 0.8 Hours
Core Tip

Core Tip: Involuntary or voluntary exposure to gluten can lead to severe and persistent symptoms in celiac patients on long-term gluten-free diets. Aspergillus niger prolyl endopeptidase metabolizes gluten before it reaches the small intestine, reducing the celiac disease-specific symptoms. That was demonstrated by the decrease in the concentration of gluten immunogenic peptide.