Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2024; 30(23): 2931-2933
Published online Jun 21, 2024. doi: 10.3748/wjg.v30.i23.2931
Understanding the molecular crossroads in acute liver failure: A pathway to new therapies
Chun-Yao Cheng, Wen-Rui Hao, Tzu-Hurng Cheng
Chun-Yao Cheng, Department of Medical Education, National Taiwan University Hospital, Taipei 100225, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei 23561, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11002, Taiwan
Tzu-Hurng Cheng, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung 404333, Taiwan
Co-first authors: Chun-Yao Cheng and Wen-Rui Hao.
Author contributions: Cheng CY and Hao WR contributed equally; Cheng CY wrote the paper; Hao WH and Cheng TH revised the paper; All authors have read and approve the final manuscript.
Supported by China Medical University, No. CMU111-MF-10.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung 404333, Taiwan. thcheng@mail.cmu.edu.tw
Received: February 24, 2024
Revised: April 30, 2024
Accepted: May 24, 2024
Published online: June 21, 2024
Processing time: 117 Days and 4.4 Hours
Core Tip

Core Tip: Understanding the interplay between ferroptosis and pyroptosis is crucial for delineating the complex pathophysiology of acute liver failure (ALF). Targeting key regulators of these cell death pathways, particularly silent information regulator sirtuin 1, holds promise for the development of novel therapeutic strategies for mitigating hepatocyte injury and improving clinical outcomes in patients with ALF. Multidisciplinary collaborations that integrate basic science, translational research, and clinical trials should be conducted to accelerate the translation of the experimental findings into effective treatments for this life-threatening condition.