Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2024; 30(23): 2927-2930
Published online Jun 21, 2024. doi: 10.3748/wjg.v30.i23.2927
Close relationship between mediators of inflammation and pancreatic cancer: Our experience
Francesca Vescio, Michele Ammendola, Giuseppe Currò, Silvia Curcio
Francesca Vescio, Giuseppe Currò, Silvia Curcio, Science of Health Department, General Surgery Unit, University “Magna Graecia” Medical School, University Hospital “R. Dulbecco”, Catanzaro 88100, Italy
Michele Ammendola, Science of Health Department, Digestive Surgery Unit, University “Magna Graecia” Medical School, University Hospital “R. Dulbecco”, Catanzaro 88100, Italy
Author contributions: Ammendola M initiated the idea of writing up the editorial; Vescio F and Curcio S contributed to the manuscript writing equally and performed the bibliographic search; Currò G revised the final paper; All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Michele Ammendola, MD, Professor, Science of Health Department, Digestive Surgery Unit, University “Magna Graecia” Medical School, University Hospital “R. Dulbecco”, Viale Europa Loc Germaneto, Catanzaro 88100, Italy. michele.ammendola@unicz.it
Received: January 13, 2024
Revised: May 4, 2024
Accepted: May 27, 2024
Published online: June 21, 2024
Processing time: 159 Days and 5.9 Hours
Core Tip

Core Tip: This editorial focuses on the mechanisms that link pancreatic inflammation to pancreatic cancer. Pancreatic cancer remains one of the most aggressive pathologies. A better understanding of its etiology and the identification of risk factors is essential for primary prevention. Mast cells (MCs) contain pro-angiogenic factors, particularly tryptase, that are associated with increased angiogenesis. We evaluated the role of MCs in angiogenesis in both pancreatic ductal adenocarcinoma tissue and adjacent normal tissue by assessing the density of c-Kit receptor-positive MCs, the density of tryptase-positive MCs, the area of tryptase-positive MCs, and microvascularization density.