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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2024; 30(21): 2751-2762
Published online Jun 7, 2024. doi: 10.3748/wjg.v30.i21.2751
Published online Jun 7, 2024. doi: 10.3748/wjg.v30.i21.2751
Effects of proton pump inhibitors on inflammatory bowel disease: An updated review
Yu Liang, Man Jiang, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Zhen Meng, Department of Intervention, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Xue-Li Ding, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Jiang M designed the study; Liang Y drafted the manuscript; Meng Z drew the pictures; Jiang M and Ding XL revised the manuscript; and all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Man Jiang, PharmD, Chief Pharmacist, Director, Professor, Department of Pharmacy, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, Shandong Province, China. jasmanouc@163.com
Received: February 2, 2024
Revised: April 26, 2024
Accepted: May 15, 2024
Published online: June 7, 2024
Processing time: 121 Days and 23.5 Hours
Revised: April 26, 2024
Accepted: May 15, 2024
Published online: June 7, 2024
Processing time: 121 Days and 23.5 Hours
Core Tip
Core Tip: Inflammatory bowel disease (IBD) can be induced by multiple factors. Incidentally, several drugs, including proton pump inhibitors (PPIs), may also be involved in the occurrence and development of IBD. This study is an updated review of the literature. It summarizes the potential impact of PPIs on the risk, severity, and pharmacotherapy of IBD and analyzes the possible mechanisms through which PPIs may contribute to the development of IBD.